Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | EIF4A1 | P60842 | 5/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221794 | 0.85 | EIF4A1 (0.51) | KDM4EALDH1A1LMNAMAPTCTRC | |
| SCHEMBL14409797 | 0.72 | CTSV (0.47) | KDM4EALDH1A1MAPTDHODHGCGR | |
| SCHEMBL9945516 | 0.70 | RAB9A (0.50) | KDM4EALDH1A1MAPTCTRCGCGR | |
| SCHEMBL22607015 | 0.68 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTOPRK1 | |
| SCHEMBL15868702 | 0.68 | CA2 (0.54) | KDM4EALDH1A1LMNARARB | |
| SCHEMBL23291935 | 0.68 | DHODH (0.56) | KDM4EALDH1A1DHODHPSMB5HSD11B1 | |
| SCHEMBL11655672 | 0.68 | SKP2 (0.39) | LMNACTRCEIF4A1DHODHKMT2A | |
| SCHEMBL29992999 | 0.67 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTDHODH | |
| SCHEMBL17367223 | 0.67 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTDHODH | |
| SCHEMBL19639039 | 0.67 | KDM4E (0.71) | KDM4EALDH1A1LMNAMAPTDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618094-B1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | INST FOR PHARM DISCOVERY INC (US) | 2007-09-05 | — | — | EP | disclosed |