Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ADK | P55263 | 11/20 | 0.53 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933892 | 0.86 | MTOR (0.52) | MTORRAB9AADKHASPINSRC | |
| SCHEMBL16237288 | 0.85 | SRC (0.59) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL16655499 | 0.83 | MTOR (0.55) | MTORRAB9AADKHASPINSRC | |
| SCHEMBL1933267 | 0.83 | RIPK2 (0.63) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL1933264 | 0.83 | RIPK2 (0.63) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL1940882 | 0.82 | ABL1 (0.64) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL30155310 | 0.82 | ABL1 (0.64) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL400626 | 0.82 | SRC (0.61) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL29484468 | 0.82 | SRC (0.61) | MTORRAB9AADKSRCABL1 | |
| SCHEMBL24650661 | 0.81 | MTOR (0.55) | MTORRAB9AADKHASPINSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683722-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | Novartis AG (CH) | 2014-01-15 | — | — | EP | disclosed |
| US-20130338152-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | IRM LLC (BM) | 2013-12-19 | — | — | US | disclosed |
| WO-2012120469-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012120469-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |
| EP-2475668-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| CN-102596963-A | Ether derivatives of bicyclic heteroaryls | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
| WO-2011029915-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130338152-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | IGF1R, IGFBP1, IGFBP2 | MTOR 134/4885RAB9A 2061/4885ADK 2073/4885 |
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | MTOR 1267/4885RAB9A 2387/4885ADK 3449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.