Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.48 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928927 | 0.74 | PIM1 (0.67) | PIM1PIM2PIP4K2APIP4K2BMEN1 | |
| SCHEMBL6928923 | 0.74 | PIM1 (0.67) | PIM1PIM2PIP4K2APIP4K2BMEN1 | |
| SCHEMBL14423939 | 0.74 | HDAC1 (0.44) | MEN1POLBKMT2A | |
| SCHEMBL6929933 | 0.73 | KMT2A (0.51) | PIM1PIM2MEN1POLBKMT2A | |
| SCHEMBL6929936 | 0.73 | KMT2A (0.51) | PIM1PIM2MEN1POLBKMT2A | |
| SCHEMBL14198606 | 0.72 | MEN1 (0.75) | PIM1PIM2MEN1POLBKMT2A | |
| SCHEMBL14423934 | 0.72 | CA2 (0.40) | MEN1KMT2A | |
| SCHEMBL6928481 | 0.72 | PIM1 (0.67) | PIM1PIM2PIP4K2APIP4K2BAKR1B1 | |
| SCHEMBL6928484 | 0.72 | PIM1 (0.67) | PIM1PIM2PIP4K2APIP4K2BAKR1B1 | |
| SCHEMBL6925746 | 0.71 | PIM1 (0.69) | PIM1PIM2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |