Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14423923 | 0.76 | AKR1C3 (0.58) | HDAC8HDAC2HDAC6MAPTALDH1A1 | |
| SCHEMBL14423936 | 0.74 | PIM1 (0.48) | MEN1KMT2APOLB | |
| SCHEMBL14198608 | 0.72 | CA1 (0.48) | — | |
| SCHEMBL14423938 | 0.71 | PGR (0.43) | HDAC1HDAC8MAPTALDH1A1HPGD | |
| SCHEMBL396988 | 0.69 | HDAC1 (0.60) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL396989 | 0.69 | HDAC1 (0.60) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14423934 | 0.69 | CA2 (0.40) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14423937 | 0.68 | PTPN1 (0.44) | MAPTALDH1A1HPGDPIK3CAHTR6 | |
| SCHEMBL23511012 | 0.67 | HDAC1 (0.75) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL15652924 | 0.66 | HDAC1 (0.64) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |