Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14423923 | 0.75 | AKR1C3 (0.58) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL1692226 | 0.73 | HTR6 (0.63) | PGRHTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL14423937 | 0.73 | PTPN1 (0.44) | PGRHTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL14423939 | 0.71 | HDAC1 (0.44) | PGRHTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL14198609 | 0.71 | CA2 (0.50) | — | |
| SCHEMBL1696862 | 0.69 | HTR6 (0.68) | PGRHTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL14423934 | 0.68 | CA2 (0.40) | PGRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL27387852 | 0.65 | KMT2A (0.58) | PGRHTR6KMT2AMEN1ALDH1A1 | |
| SCHEMBL18970321 | 0.64 | TNNI3K (0.46) | HTR6KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL8429305 | 0.64 | HDAC1 (0.65) | PGRHTR6KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |