Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.54 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | MMP12 | P39900 | 5/20 | 0.47 |
| ▸ | MMP14 | P50281 | 5/20 | 0.47 |
| ▸ | MMP15 | P51511 | 5/20 | 0.47 |
| ▸ | MMP16 | P51512 | 5/20 | 0.47 |
| ▸ | MMP26 | Q9NRE1 | 5/20 | 0.47 |
| ▸ | MMP7 | P09237 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14427217 | 0.94 | MMP1 (0.54) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427225 | 0.90 | MMP1 (0.68) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL5434029 | 0.85 | MMP1 (0.46) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427214 | 0.84 | MMP1 (0.68) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427176 | 0.83 | MMP1 (0.49) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427223 | 0.81 | MMP8 (0.60) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427204 | 0.80 | MMP8 (0.54) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL12955748 | 0.80 | THRB (0.52) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427229 | 0.80 | THRB (0.52) | MMP1MMP2MMP9MMP12MMP14 | |
| SCHEMBL14427231 | 0.80 | THRB (0.52) | MMP1MMP2MMP9MMP12MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | MMP9, MMP2, MMP3 | MMP1 8/4885MMP2 2/4885MMP9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.