Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PHF13 | Q86YI8 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14430739 | 0.74 | L3MBTL3 (0.53) | CYP2D6MAPTRECQLATMKMT2A | |
| SCHEMBL7399854 | 0.74 | HTR1A (0.73) | CYP2D6HTR1ADRD2HTR2A | |
| SCHEMBL14430744 | 0.72 | MAPT (0.46) | ACHEMAPTRECQLKMT2AL3MBTL1 | |
| SCHEMBL7396267 | 0.71 | HTR1A (0.78) | HTR1ADRD2HTR2A | |
| SCHEMBL14430754 | 0.68 | STAT3 (0.50) | MAPTRECQLKMT2AL3MBTL1TSHR | |
| SCHEMBL14430745 | 0.68 | KMT2A (0.53) | MAPTRECQLKMT2AL3MBTL1TSHR | |
| SCHEMBL14430724 | 0.68 | MAPT (0.54) | ACHECYP2D6MAPTRECQLKMT2A | |
| SCHEMBL5474202 | 0.68 | ALDH1A1 (0.71) | CYP2D6MAPTRECQLKMT2AL3MBTL1 | |
| SCHEMBL14430740 | 0.68 | MAPT (0.59) | CYP2D6MAPTRECQLKMT2AL3MBTL1 | |
| SCHEMBL14430792 | 0.68 | POLB (0.56) | CYP2D6MAPTRECQLL3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | ACHE 1087/4885CYP2D6 369/4885MAPT 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.