Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 8/20 | 0.46 |
| ▸ | NOS1 | P29475 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13314521 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL29776903 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL29424531 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL59519 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL30287655 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL59520 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL4542003 | 0.95 | HSD17B10 (0.69) | HSD17B10AKR1B1NOS1 | |
| Mannitol SCHEMBL21903100 | 0.92 | HSD17B10 (0.68) | HSD17B10AKR1B1NOS1 | |
| Xylitol SCHEMBL18285153 | 0.92 | HSD17B10 (0.68) | HSD17B10AKR1B1NOS1 | |
| SCHEMBL12559328 | 0.85 | HSD17B10 (0.66) | HSD17B10AKR1B1NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138142-A1 | COMPOSITIONS AND USE OF SULFASALAZINE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2011-11-10 | — | — | WO | claimed |
| CN-107614688-B | Microorganisms producing benzylisoquinoline alkaloid (BIA) precursors and methods of making and using same | 小利兰·斯坦福大学托管委员会 | 2023-02-28 | — | — | CN | disclosed |
| CN-105829541-B | Microorganisms producing benzylisoquinoline alkaloid (BIA) precursors and methods of making and using the same | 小利兰·斯坦福大学托管委员会 | 2022-08-12 | — | — | CN | disclosed |
| CN-112410379-A | Microorganisms producing benzylisoquinoline alkaloid (BIA) precursors and methods of making and using the same | 小利兰·斯坦福大学托管委员会 | 2021-02-26 | — | — | CN | disclosed |
| EP-2201107-B1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | UNIV WESTERN HEALTH SCIENCES (US) | 2019-01-16 | — | — | EP | disclosed |
| US-20130218546-A1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130210826-A1 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2013-08-15 | — | — | US | disclosed |
| US-8328934-B2 | Crystal of GTP Cyclohydrolase Type IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| WO-2011138142-A1 | COMPOSITIONS AND USE OF SULFASALAZINE | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2011-11-10 | — | — | WO | disclosed |
| US-20100291608-A1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-11-18 | — | — | US | disclosed |
| EP-2201107-A2 | NOVEL GTP CYCLOHYDROLASE TYPE IB | Western University Of Health Sciences (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2010039115-A9 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010039115-A2 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-04-08 | — | — | WO | disclosed |
| EP-1696877-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050197341-A1 | Methods for treating pain | GENERAL HOSPITAL CORPORATION, THE | 2005-09-08 | — | — | US | disclosed |
| WO-2005048926-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
| US-6103226-A | CO-TRANSFECTING THE CELL WITH ONE OR MORE EXPRESSION VECTORS CONTAINING POLYNUCLEOTIDES THAT ENCODE TYROSINE HYDROXYLASE, AROMATIC L-AMINO ACID DECARBOXYLASE AND GTP CYCLOHYDROLASE. | ARCH DEVELOPMENT CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| US-5846775-A | GTP cyclohydrolase I regulatory protein | INCYTE PHARMACEUTICALS, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1996005319-A1 | GENETICALLY ENGINEERED CELLS THAT PRODUCE DOPAMINE | ARCH DEVELOPMENT CORPORATION (US) | 1996-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210826-A1 | METHODS FOR TREATING PAIN | SPR, QDPR, SHMT1 | HSD17B10 307/4885AKR1B1 159/4885NOS1 1639/4885 |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | GGH, GGPS1, GGT1 | HSD17B10 666/4885AKR1B1 469/4885NOS1 1243/4885 |
| US-20050197341-A1 | Methods for treating pain | SPR, QDPR, SHMT1 | HSD17B10 323/4885AKR1B1 110/4885NOS1 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.