SCHEMBL1446151

SCHEMBL1446151

CC(C)(Cl)C(=O)c1ccc(Oc2ccc(C(=O)C(C)(C)Cl)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.54
MAPT P10636 1/20 0.54
RAB9A P51151 1/20 0.54
ELANE P08246 4/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
ALDH1A1 P00352 2/20 0.48
TSHR P16473 1/20 0.48
HTT P42858 1/20 0.48
PARP10 Q53GL7 7/20 0.48
PARP15 Q460N3 2/20 0.48
KMT2A Q03164 1/20 0.48
PARP14 Q460N5 1/20 0.48
PARP16 Q8N5Y8 1/20 0.48
PARP11 Q9NR21 1/20 0.48
PARP4 Q9UKK3 1/20 0.48
ESRRA P11474 1/20 0.44
MMP13 P45452 1/20 0.43
SRD5A2 P31213 1/20 0.41
PARP3 Q9Y6F1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1446271 0.87 HPGD (0.42) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL1446163 0.85 HPGD (0.56) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL24813408 0.83 HPGD (0.58) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL10347639 0.83 PARP10 (0.52) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL9639571 0.83 PARP10 (0.52) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL1446152 0.82 MAPK14 (0.39) HPGDMAPTRAB9ASMN1; SMN2TSHR
SCHEMBL195348 0.81 HPGD (0.56) HPGDMAPTRAB9AELANESMN1; SMN2
SCHEMBL4421929 0.80 ALDH1A1 (0.48) HPGDMAPTELANEALDH1A1HTT
SCHEMBL1553905 0.79 PARP10 (0.56) HPGDMAPTRAB9ASMN1; SMN2ALDH1A1
SCHEMBL11530823 0.79 ELANE (0.56) HPGDMAPTRAB9AELANESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111138260-B Preparation method of alpha-hydroxyketone bifunctional photoinitiator 天津久日新材料股份有限公司 2022-10-14 CN claimed
CN-111138260-A Preparation method of α -hydroxyketone bifunctional photoinitiator 天津久日新材料股份有限公司 2020-05-12 CN claimed
EP-1692088-B1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF LAMBERTI SPA (IT) 2009-12-02 EP claimed
JP-2007513069-A 2007-05-24 JP claimed
EP-1692088-A1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF Lamberti Spa (IT) 2006-08-23 EP claimed
WO-2005040083-A1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF LAMBERTI SPA (IT) 2005-05-06 WO claimed
CN-111138260-B Preparation method of alpha-hydroxyketone bifunctional photoinitiator 天津久日新材料股份有限公司 2022-10-14 CN disclosed
CN-111138260-A Preparation method of α -hydroxyketone bifunctional photoinitiator 天津久日新材料股份有限公司 2020-05-12 CN disclosed
EP-1523506-B1 NEW DIFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2012-09-12 EP disclosed
EP-2297076-A1 PROCESS FOR THE PREPARATION OF AROMATIC ALPHA-HYDROXY KETONES Lamberti SpA (IT) 2011-03-23 EP disclosed
US-20110065962-A1 PROCESS FOR THE PREPARATION OF AROMATIC ALPHA-HYDROXY KETONES MENEGUZZO ENZO 2011-03-17 US disclosed
US-7723397-B2 ethylenically unsaturated aminoacrylates; overprinting; for production of scratch-resistant durable surface CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-05-25 US disclosed
EP-1692088-B1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF LAMBERTI SPA (IT) 2009-12-02 EP disclosed
US-20070135531-A1 White solid photoinitiator in the form of powder and preparation thereof IGM GROUP BV (NL) 2007-06-14 US disclosed
EP-1692088-A1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF Lamberti Spa (IT) 2006-08-23 EP disclosed
US-20050239971-A1 New difunctional photoinitators IGM GROUP B.V. (NL) 2005-10-27 US disclosed
CN-1668648-A Novel bifunctional photoinitiators CIBA SC HOLDING AG (CH) 2005-09-14 CN disclosed
WO-2005040083-A1 WHITE SOLID PHOTOINITIATOR IN THE FORM OF POWDER AND PREPARATION THEREOF LAMBERTI SPA (IT) 2005-05-06 WO disclosed
EP-1523506-A1 NEW DIFUNCTIONAL PHOTOINITIATORS Ciba SC Holding AG (CH) 2005-04-20 EP disclosed
WO-2004009651-A1 NEW DIFUNCTIONAL PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065962-A1 PROCESS FOR THE PREPARATION OF AROMATIC ALPHA-HYDROXY KETONES KHK, BCKDK, PAH HPGD 1502/4885MAPT 2526/4885RAB9A 3417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.