Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 4/20 | 0.43 |
| ▸ | PRKCB | P05771 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463439 | 0.81 | NPSR1 (0.51) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL12660357 | 0.73 | SIRT1 (0.52) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL14463525 | 0.72 | PRKCB (0.47) | ALDH1A1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL7284139 | 0.72 | MAPT (0.50) | JAK1JAK3PDGFRBKDM4EALDH1A1 | |
| SCHEMBL12672661 | 0.72 | ALDH1A1 (0.40) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL14463494 | 0.72 | CASP1 (0.61) | CASP3KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL6395311 | 0.70 | APAF1 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL1896021 | 0.69 | MEN1 (0.59) | KDM4EALDH1A1MAPTMEN1HPGD | |
| SCHEMBL18949722 | 0.68 | AHR (0.57) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL4764396 | 0.67 | APAF1 (0.65) | APAF1CDC25BCASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007064345-A9 | HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE | GENENTECH INC (US) | 2007-07-12 | — | — | WO | disclosed |