Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984896 | 0.83 | GSK3B (0.52) | GSK3BL3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL28214996 | 0.83 | NPC1 (0.48) | L3MBTL1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL13857466 | 0.81 | GSK3B (0.55) | GSK3BNPC1RAB9ACES2CES1 | |
| SCHEMBL34473284 | 0.81 | MEN1 (0.38) | GSK3BNPC1RAB9AMAPTTSHR | |
| SCHEMBL13817452 | 0.81 | NPC1 (0.50) | NPC1RAB9AMAPTCES2CES1 | |
| SCHEMBL13525672 | 0.81 | KMT2A (0.50) | GSK3BL3MBTL1NPC1RAB9AERCC5 | |
| SCHEMBL26922809 | 0.81 | KMO (0.47) | TSHRKDM4EALDH1A1HSD11B1POLB | |
| SCHEMBL23553623 | 0.80 | ERCC5 (0.51) | ERCC5FEN1MAPTALDH1A1KMT2A | |
| SCHEMBL30041147 | 0.80 | ERCC5 (0.51) | ERCC5FEN1MAPTALDH1A1KMT2A | |
| SCHEMBL16322250 | 0.78 | ALDH1A1 (0.47) | L3MBTL1MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511192-B | Benzamide compound and synthesis method thereof | 武汉工程大学 | 2023-03-31 | — | — | CN | claimed |
| CN-110511193-B | Alpha-ketothioamide compound and synthetic method thereof | 武汉工程大学 | 2023-03-21 | — | — | CN | claimed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| CN-114450281-B | Inhibitor compounds | 辛塞拉治疗私人有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-113166134-B | Pyrrolidone derivatives as formyl peptide 2 receptor agonists | 百时美施贵宝公司 | 2024-06-14 | — | — | CN | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| EP-3887366-B1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-27 | — | — | EP | disclosed |
| CN-110511193-B | Alpha-ketothioamide compound and synthetic method thereof | 武汉工程大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-114450281-A | Inhibitor compounds | 辛塞拉治疗私人有限公司 | 2022-05-06 | — | — | CN | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | GSK3B 3565/4885L3MBTL1 1982/4885NPC1 2495/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | GSK3B 3565/4885L3MBTL1 1982/4885NPC1 2495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.