Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469296 | 0.86 | KMT2A (0.43) | SMN1; SMN2L3MBTL1GAAMEN1KMT2A | |
| SCHEMBL14469573 | 0.79 | MTNR1B (0.39) | SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL14469365 | 0.77 | KDM4E (0.48) | SMN1; SMN2GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL14469188 | 0.76 | ALDH1A1 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14469294 | 0.75 | ALDH1A1 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14469186 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14469563 | 0.74 | KDM4E (0.37) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14469234 | 0.74 | ALDH1A1 (0.38) | SMN1; SMN2L3MBTL1GAAKMT2AALDH1A1 | |
| SCHEMBL14469298 | 0.74 | MEN1 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14469170 | 0.73 | KDM4E (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |