Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469559 | 0.83 | KDM4E (0.46) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469563 | 0.81 | KDM4E (0.37) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469555 | 0.81 | SMN1; SMN2 (0.48) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469115 | 0.78 | MEN1 (0.49) | KDM4EPOLBTSHRALDH1A1ALOX15 | |
| SCHEMBL14469551 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1ALOX15TDP1 | |
| SCHEMBL14469477 | 0.77 | KMT2A (0.58) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469475 | 0.77 | ALDH1A1 (0.47) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469365 | 0.76 | KDM4E (0.48) | KDM4EPOLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469474 | 0.76 | MTNR1B (0.49) | KDM4ESMN1; SMN2TSHRALDH1A1ALOX15 | |
| SCHEMBL14469560 | 0.76 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2TSHRALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |