Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 12/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5289517 | 0.83 | CSF1R (0.47) | LMNAPOLBCSF1RTHRBHTT | |
| SCHEMBL11022041 | 0.77 | CSF1R (0.53) | LMNACSF1RHTTL3MBTL1ALDH1A1 | |
| SCHEMBL4060937 | 0.76 | CSF1R (0.58) | LMNACSF1RTHRBHTTALDH1A1 | |
| SCHEMBL11016941 | 0.74 | CSF1R (0.57) | LMNAPOLBCSF1RTHRBHTT | |
| SCHEMBL7207413 | 0.68 | LMNA (0.61) | LMNAPOLBCNR2THRBHTT | |
| SCHEMBL5879414 | 0.67 | LMNA (0.65) | LMNAPOLBCNR2THRBHTT | |
| SCHEMBL19431668 | 0.67 | MEN1 (0.60) | LMNAPOLBCNR2THRBHTT | |
| SCHEMBL17617963 | 0.67 | LMNA (0.60) | LMNAPOLBCNR2THRBHTT | |
| SCHEMBL1948564 | 0.66 | CNR2 (0.50) | LMNAPOLBCNR2THRBHTT | |
| SCHEMBL14619635 | 0.66 | LMNA (0.44) | LMNAPOLBCNR2THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |