Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171430 | 0.77 | MEN1 (0.69) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL1053419 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL4314000 | 0.76 | LMNA (0.50) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL353890 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL149707 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| Ammonia Solution, Strong SCHEMBL19182582 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| Bromide SCHEMBL11628983 | 0.74 | LMNA (0.49) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL8395946 | 0.74 | NOS2 (0.61) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| Bromide SCHEMBL5318089 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2ATMKDM4ERAB9ANPC1 | |
| SCHEMBL8956213 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2ATMKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355609-A1 | Spirolactone Compounds | QUIXGEN, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230355609-A1 | Spirolactone Compounds | QUIXGEN, INC. (US) | 2023-11-09 | — | — | US | disclosed |
| US-11541046-B2 | Spirolactone compounds | QUIXGEN, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210145822-A1 | Novel Spirolactone Compounds | QUIXGEN, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| WO-2019006324-A1 | NOVEL SPIROLACTONE COMPOUNDS | QUIXGEN, INC. (US) | 2019-01-03 | — | — | WO | disclosed |
| EP-2881394-A1 | CONDENSED RING HETEROCYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2015-06-10 | — | — | EP | disclosed |
| US-20120056529-A1 | 3-COORDINATE COPPER(I)-CARBENE COMPLEXES | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-03-08 | — | — | US | disclosed |
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
| US-20100041891-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541046-B2 | Spirolactone compounds | ACACA, AKR1C2, AKR1A1 | SMN1; SMN2 3511/4885ATM 674/4885KDM4E 4368/4885 |
| US-20120056529-A1 | 3-COORDINATE COPPER(I)-CARBENE COMPLEXES | AOC3, AOC2, OCIAD1 | SMN1; SMN2 3669/4885ATM 4648/4885KDM4E 4846/4885 |
| US-20100041891-A1 | AMIDE COMPOUND | GPR52, GPR132, NR5A2 | SMN1; SMN2 4263/4885ATM 4570/4885KDM4E 3467/4885 |
| US-20210145822-A1 | Novel Spirolactone Compounds | ACACA, HSD17B10, AKR1C2 | SMN1; SMN2 3594/4885ATM 826/4885KDM4E 4385/4885 |
| US-20230355609-A1 | Spirolactone Compounds | ACACA, AKR1C2, AKR1A1 | SMN1; SMN2 3511/4885ATM 674/4885KDM4E 4368/4885 |
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | SMN1; SMN2 4711/4885ATM 3884/4885KDM4E 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.