Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504422 | 0.85 | TAAR1 (0.36) | P2RX7TDP1TAAR1MAPT | |
| SCHEMBL2403273 | 0.84 | L3MBTL1 (0.40) | P2RX7MEN1KMT2AHSD17B10 | |
| SCHEMBL10258195 | 0.82 | NLRP3 (0.43) | P2RX7KMT2ATDP1HSD17B10 | |
| SCHEMBL14499486 | 0.78 | P2RX7 (0.39) | P2RX7KDM5AKDM4CKDM5BPOLB | |
| SCHEMBL13949103 | 0.77 | P2RX7 (0.45) | P2RX7GAAPDE10AMAPTHSD17B10 | |
| SCHEMBL6215461 | 0.77 | NPC1 (0.41) | P2RX7TSHRMEN1GAAKMT2A | |
| SCHEMBL11889021 | 0.74 | FFAR1 (0.38) | P2RX7POLB | |
| SCHEMBL5545008 | 0.72 | SRC (0.59) | P2RX7MEN1GAAKMT2AMAPT | |
| SCHEMBL10862456 | 0.72 | P2RX7 (0.45) | P2RX7KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL29237462 | 0.71 | ALDH1A1 (0.33) | P2RX7MEN1KMT2ATAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226951-B2 | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same | ALLERGAN, INC. (US) | 2007-06-05 | — | — | US | disclosed |