Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.89 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.89 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.56 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 5/20 | 0.89 |
| ▸ | CCR8 | P51685 | 5/20 | 0.89 |
| ▸ | LMNA | P02545 | 4/20 | 0.89 |
| ▸ | CCR5 | P51681 | 3/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.89 |
| ▸ | MMP2 | P08253 | 2/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | MAPT | P10636 | 2/20 | 0.89 |
| ▸ | HTT | P42858 | 2/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.89 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.89 |
| ▸ | GMNN | O75496 | 1/20 | 0.89 |
| ▸ | TP53 | P04637 | 1/20 | 0.89 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL31091571 | 1.00 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL30486910 | 1.00 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL999010 | 1.00 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL5465049 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8686807 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL44857 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL28662342 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL1730256 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL31300436 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL30477083 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114527-B1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | ST JUDE MEDICAL (SE) | 2018-08-22 | — | — | EP | disclosed |
| EP-2150176-B1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | ST JUDE MEDICAL (SE) | 2016-04-27 | — | — | EP | disclosed |
| US-8637331-B2 | Transparent polarized light-emitting device | BLOOMINESCENCE, LLC (US) | 2014-01-28 | — | — | US | disclosed |
| EP-2129433-B1 | IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR | ST JUDE MEDICAL (SE) | 2013-10-16 | — | — | EP | disclosed |
| US-20120315714-A1 | TRANSPARENT POLARIZED LIGHT-EMITTING DEVICE | BLOOMINESCENCE LLC (US) | 2012-12-13 | — | — | US | disclosed |
| US-8253153-B2 | Transparent polarized light-emitting device | BLOOMINESCENCE, LLC (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2370985-A1 | TRANSPARENT POLARIZED LIGHT-EMITTING DEVICE | Bloominescence LLC (US) | 2011-10-05 | — | — | EP | disclosed |
| US-7910272-B2 | Dye-containing photosensitive composition, color filter using the same, and production method thereof | FUJIFILM CORPORATION (JP) | 2011-03-22 | — | — | US | disclosed |
| US-20100185252-A1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | ST. JUDE MEDICAL AB (SE) | 2010-07-22 | — | — | US | disclosed |
| US-20100130839-A1 | IMPLANTABLE DEVICES AND METHOD FOR DETERMINING A CONCENTRATION OF A SUBSTANCE AND/OR MOLECULE IN BLOOD OR TISSUE OF A PATIENT | ST. JUDE MEDICAL AB | 2010-05-27 | — | — | US | disclosed |
| WO-2010045606-A1 | TRANSPARENT POLARIZED LIGHT-EMITTING DEVICE | BLOOMINESCENCE, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20100096617-A1 | TRANSPARENT POLARIZED LIGHT-EMITTING DEVICE | BLOOMINESCENCE, INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-20070190435-A1 | Dye-containing photosensitive composition, color filter using the same, and production method thereof | FUJIFILM CORPORATION (JP) | 2007-08-16 | — | — | US | disclosed |
| US-20070184366-A1 | DYE CONTAINING CURABLE COMPOSITION, COLOR FILTER, AND PROCESS OF PREPARING COLOR FILTER | FUJIFILM CORPORATION | 2007-08-09 | — | — | US | disclosed |
| US-20070099096-A1 | Dye-containing curable composition, color filter and method of producing thereof | FUJIFILM CORPORATION | 2007-05-03 | — | — | US | disclosed |
| US-20040185372-A1 | Dye-containing curable composition, color filter, and process of preparing color filter | FUJI PHOTO FILM CO., LTD. | 2004-09-23 | — | — | US | disclosed |
| US-20010034479-A1 | Optically based transcutaneous blood gas sensor | PALCO LABS, INC. | 2001-10-25 | — | — | US | disclosed |