SCHEMBL1452071

SCHEMBL1452071

O=C1CCOc2cc(C(F)(F)F)ccc21

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 14/20 0.58
MAOA P21397 1/20 0.58
GRM5 P41594 8/20 0.50
NPC1 O15118 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
NFKB1 P19838 1/20 0.46
RAB9A P51151 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
PRMT5 O14744 1/20 0.42
WDR77 Q9BQA1 1/20 0.42
CHEK1 O14757 1/20 0.40
FLT3 P36888 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29758931 1.00 MAOB (0.58) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL1450607 0.90 MAOB (0.47) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL30953601 0.90 MAOB (0.47) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL17362041 0.88 MAOB (0.53) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL86946 0.87 MAOB (0.46) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL30574501 0.87 MAOB (0.46) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL30132637 0.84 MAOB (0.52) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL20554219 0.84 MAOB (0.52) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL696080 0.83 MAOB (0.58) MAOBMAOAGRM5NPC1ALDH1A1
SCHEMBL2930402 0.83 MAPT (0.47) MAOBMAOAALDH1A1PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125380-A1 PRMT5 INHIBITORS AND METHODS OF USE SHANGHAI APEIRON THERAPEUTICS COMPANY LIMITED (CN) 2026-05-07 US disclosed
EP-4592289-A1 NOVEL PRMT5 INHIBITOR AND USE THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2025-07-30 EP disclosed
US-20250051331-A1 PRMT5 INHIBITORS AND METHODS OF USE SHANGHAI APEIRON THERAPEUTICS COMPANY LIMITED (CN) 2025-02-13 US disclosed
US-12173002-B2 PRMT5 inhibitors and methods of use SHANGHAI APEIRON THERAPEUTICS COMPANY LIMITED (CN) 2024-12-24 US disclosed
US-20240368177-A1 5-AMINO-6,8-DIHYDRO-1H-FURO[3,4-d]PYRROLO[3,2-b]PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 BEIGENE SWITZERLAND GMBH (CH) 2024-11-07 US disclosed
US-20240294528-A1 PRMT5 INHIBITORS AND METHODS OF USE SHANGHAI APEIRON THERAPEUTICS COMPANY LIMITED (CN) 2024-09-05 US disclosed
US-20240182436-A1 SUBSTITUTED SULFONAMIDE-CHROMAN COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF SUMITOMO PHARMA AMERICA, INC. (US) 2024-06-06 US disclosed
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2024-02-15 US disclosed
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-09-14 US disclosed
US-11725001-B2 Bicyclic compound and use thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2023-08-15 US disclosed
US-20090093472-A1 ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION PHARMACOPEIA, INC. (US) 2009-04-09 US disclosed
CN-101365684-A Indazole derivatives inhibiting TRPV1 receptor ABBOTT LAB (US) 2009-02-11 CN disclosed
US-20080287428-A1 Novel Heterocyclidene Acetamide Derivative MOCHIDA PHARMACEUTICAL CO.,LTD (JP) 2008-11-20 US disclosed
EP-1957464-A1 INDAZOLE DERIVATIVES THAT INHIBIT TRPVl RECEPTOR Abbott Laboratories (US) 2008-08-20 EP disclosed
EP-1908753-A1 NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2008-04-09 EP disclosed
EP-1844038-A2 CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF ABBOTT LABORATORIES (US) 2007-10-17 EP disclosed
WO-2007050732-A1 INDAZOLE DERIVATIVES THAT INHIBIT TRPVl RECEPTOR ABBOTT LABORATORIES (US) 2007-05-03 WO disclosed
US-20070099954-A1 Prodrugs of compounds that inhibit TRPV1 receptor ABBVIE INC. 2007-05-03 US disclosed
WO-2006065484-A2 CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF ABBOTT LABORATORIES (US) 2006-06-22 WO disclosed
US-20060128689-A1 Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof ABBVIE INC. 2006-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060128689-A1 Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof CACNA1E, CACNA1D, CACNA1S MAOB 2316/4885MAOA 2513/4885GRM5 674/4885
US-20090093472-A1 ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION CCR1, CCR4, CCR3 MAOB 4189/4885MAOA 4653/4885GRM5 902/4885
US-12173002-B2 PRMT5 inhibitors and methods of use PRMT5, PRMT1, PRMT7 MAOB 3496/4885MAOA 3902/4885GRM5 165/4885
US-20240051951-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT1 MAOB 3338/4885MAOA 3468/4885GRM5 97/4885
US-20250051331-A1 PRMT5 INHIBITORS AND METHODS OF USE PRMT5, PRMT1, PRMT7 MAOB 3061/4885MAOA 3381/4885GRM5 264/4885
US-20230286965-A1 BICYCLIC COMPOUND AND USE THEREOF PRMT5, PRMT6, PRMT8 MAOB 3204/4885MAOA 3418/4885GRM5 144/4885
US-20080287428-A1 Novel Heterocyclidene Acetamide Derivative TRPV1, TRPV3, TRPA1 MAOB 1685/4885MAOA 1788/4885GRM5 726/4885
US-11725001-B2 Bicyclic compound and use thereof PRMT5, PRMT6, PRMT1 MAOB 3338/4885MAOA 3468/4885GRM5 97/4885
US-20240368177-A1 5-AMINO-6,8-DIHYDRO-1H-FURO[3,4-d]PYRROLO[3,2-b]PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 PRMT5, PRMT6, PRMT1 MAOB 3356/4885MAOA 3475/4885GRM5 204/4885
US-20260125380-A1 PRMT5 INHIBITORS AND METHODS OF USE PRMT1, PRMT5, PRMT6 MAOB 3907/4885MAOA 3897/4885GRM5 1158/4885
US-20240182436-A1 SUBSTITUTED SULFONAMIDE-CHROMAN COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF ARSA, SNCA, F12 MAOB 186/4885MAOA 267/4885GRM5 1572/4885
US-20070099954-A1 Prodrugs of compounds that inhibit TRPV1 receptor TRPV1, TRPV3, TRPA1 MAOB 1201/4885MAOA 1282/4885GRM5 413/4885
US-20240294528-A1 PRMT5 INHIBITORS AND METHODS OF USE PRMT5, PRMT1, PRMT3 MAOB 3700/4885MAOA 3881/4885GRM5 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.