Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240189 | 0.89 | AURKA (0.60) | AURKAAURKBLRRK2RIPK2RIPK3 | |
| SCHEMBL14536950 | 0.85 | AURKA (0.44) | AURKAAURKBSYKTTKPTK6 | |
| SCHEMBL14536853 | 0.83 | AURKA (0.46) | AURKAAURKBMAPKAPK5TTKPTK6 | |
| SCHEMBL14530183 | 0.81 | AURKA (0.45) | AURKAAURKBMAPKAPK5PRKD1TTK | |
| SCHEMBL14537040 | 0.80 | AURKA (0.48) | AURKAAURKBMAPKAPK5TTKPTK6 | |
| SCHEMBL14530182 | 0.79 | AURKA (0.53) | AURKAAURKBMAPKAPK5TTK | |
| SCHEMBL14536959 | 0.79 | TTK (0.54) | AURKAAURKBMAPKAPK5TTK | |
| SCHEMBL14537044 | 0.77 | AURKA (0.45) | AURKAAURKBMAPKAPK5SYKPRKD1 | |
| SCHEMBL14537007 | 0.77 | AURKA (0.48) | AURKAAURKBMAPKAPK5TTK | |
| SCHEMBL14530020 | 0.76 | AURKA (0.62) | AURKAAURKBMAPKAPK5TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |