Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901472 | 0.83 | APP (0.56) | APPLDHACSNK1DCSNK1G2MAPT | |
| SCHEMBL19190182 | 0.83 | APP (0.38) | APPLDHACSNK1DCSNK1G2MAPT | |
| SCHEMBL1455414 | 0.79 | APP (0.43) | APPLDHACSNK1DCSNK1G2KDM4E | |
| SCHEMBL17211305 | 0.78 | RAB9A (0.59) | APPCSNK1DCSNK1G2MAPTMEN1 | |
| SCHEMBL2078737 | 0.78 | LDHA (0.43) | APPLDHAMAPTKDM4EMEN1 | |
| SCHEMBL1455389 | 0.78 | KMT2A (0.48) | APPLDHAMAPTKDM4EMEN1 | |
| SCHEMBL3900130 | 0.78 | CSNK1D (0.42) | APPCSNK1DCSNK1G2MAPTKDM4E | |
| SCHEMBL12312871 | 0.77 | APP (0.41) | APPLDHACSNK1DCSNK1G2KDM4E | |
| SCHEMBL12312851 | 0.76 | KDM4E (0.48) | LDHAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL22585064 | 0.76 | NPC1 (0.48) | APPCSNK1DCSNK1G2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9814787-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-14 | — | — | US | disclosed |
| US-9814787-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160279268-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS | 2016-09-29 | — | — | US | disclosed |
| US-20160279268-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS | 2016-09-29 | — | — | US | disclosed |
| US-9370588-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2016-06-21 | — | — | US | disclosed |
| US-9370588-B2 | Luciferin amides | UNIVERSITY OF MASSACHUSETTS (US) | 2016-06-21 | — | — | US | disclosed |
| US-20140193340-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140193340-A1 | Luciferin Amides | UNIVERSITY OF MASSACHUSETTS (US) | 2014-07-10 | — | — | US | disclosed |
| US-20120276564-A1 | Luciferins | UNIVERSITY OF MASSACHUSETTS (US) | 2012-11-01 | — | — | US | disclosed |
| US-8216550-B2 | Luciferins | UNIVERSITY OF MASSACHUSETTS (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110136156-A1 | LUCIFERINS | UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION | 2011-06-09 | — | — | US | disclosed |
| US-7910087-B2 | Generating light | UNIVERSITY OF MASSACHUSETTS (US) | 2011-03-22 | — | — | US | disclosed |
| US-20080226557-A1 | Luciferins | UNIVERSITY OF MASSACHUSETTS | 2008-09-18 | — | — | US | disclosed |
| WO-2008109459-A1 | LUCIFERINS | UNIVERSITY OF MASSACHUSETTS (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080226557-A1 | Luciferins | GLB1, GUSB, CHLSN | APP 2491/4885LDHA 430/4885CSNK1D 3078/4885 |
| US-20160279268-A1 | Luciferin Amides | FAAH, FAAH2, MGLL | APP 1268/4885LDHA 831/4885CSNK1D 2314/4885 |
| US-20140193340-A1 | Luciferin Amides | FAAH, FAAH2, MGLL | APP 1268/4885LDHA 831/4885CSNK1D 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.