Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27584198 | 0.85 | SMN1; SMN2 (0.47) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL14557243 | 0.83 | MAPT (0.47) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL1455389 | 0.81 | KMT2A (0.48) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL544909 | 0.80 | ESR1 (0.39) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL2340714 | 0.78 | LDHA (0.71) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL1454367 | 0.78 | APP (0.43) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL14432472 | 0.78 | RAB9A (0.43) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL2804015 | 0.77 | RAB9A (0.41) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL27584164 | 0.77 | RAB9A (0.36) | LDHAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL2858603 | 0.75 | RAB9A (0.40) | LDHAMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648564-B1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2007-10-17 | — | — | EP | claimed |
| US-8080665-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-12-20 | — | — | US | disclosed |
| US-7897615-B2 | e.g. 2-Cyano-3-hydroxy-N-isopropyl-N-(2-mercapto-benzothiazol-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide; cardiovascular disorders, antidiabetic, anticarcinogenic, antiischemic agent; obesity, metabolic disorders | CHUGAI SCIYAKU KABUSHIKI KAISHA (JP) | 2011-03-01 | — | — | US | disclosed |
| US-7897615-B2 | e.g. 2-Cyano-3-hydroxy-N-isopropyl-N-(2-mercapto-benzothiazol-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide; cardiovascular disorders, antidiabetic, anticarcinogenic, antiischemic agent; obesity, metabolic disorders | CHUGAI SCIYAKU KABUSHIKI KAISHA (JP) | 2011-03-01 | — | — | US | disclosed |
| US-7786145-B2 | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-08-31 | — | — | US | disclosed |
| EP-2208495-A1 | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors | Chugai Seiyaku Kabushiki Kaisha (JP) | 2010-07-21 | — | — | EP | disclosed |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-05-14 | — | — | US | disclosed |
| US-7449482-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-11-11 | — | — | US | disclosed |
| EP-1658071-B1 | CYANOGUANIDINE-BASED AZOLE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-09-10 | — | — | EP | disclosed |
| EP-1653957-B1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-1658071-A2 | CYANOGUANIDINE-BASED AZOLE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-05-24 | — | — | EP | disclosed |
| EP-1653957-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-05-10 | — | — | EP | disclosed |
| EP-1648564-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005037258-A2 | CYANOGUANIDINE-BASED AZOLE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-04-28 | — | — | WO | disclosed |
| US-20050032824-A1 | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | US | disclosed |
| WO-2005011812-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITHORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005011812-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITHORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005011693-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | US | disclosed |
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, MCCC2 | LDHA 632/4885MAPT 2998/4885MEN1 1792/4885 |
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, PC | LDHA 822/4885MAPT 2589/4885MEN1 3120/4885 |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | ACACA, ACACB, PC | LDHA 822/4885MAPT 2589/4885MEN1 3120/4885 |
| US-20050032824-A1 | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, MLYCD, ACACB | LDHA 961/4885MAPT 3547/4885MEN1 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.