Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | GALR3 | O60755 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349533 | 0.83 | AKR1B1 (0.37) | AKR1B1MAPTGALR3THRBS100A4 | |
| SCHEMBL7350240 | 0.83 | AKR1B1 (0.35) | AKR1B1MAPTGALR3S100A4TRPV1 | |
| Hydrochloric Acid SCHEMBL2839862 | 0.82 | AKR1B1 (0.36) | AKR1B1MAPTGALR3THRBS100A4 | |
| SCHEMBL7346699 | 0.79 | ERN1 (0.36) | AKR1B1MAPTS100A4TRPV1ALDH1A1 | |
| SCHEMBL2840941 | 0.79 | ALDH1A1 (0.33) | AKR1B1MAPTS100A4TRPV1ALDH1A1 | |
| SCHEMBL13090465 | 0.77 | ACHE (0.40) | MAPTS100A4ALDH1A1MEN1KMT2A | |
| SCHEMBL2843497 | 0.77 | GPR35 (0.34) | AKR1B1MAPTS100A4TRPV1ALDH1A1 | |
| SCHEMBL2843494 | 0.77 | GPR35 (0.34) | AKR1B1MAPTS100A4TRPV1ALDH1A1 | |
| SCHEMBL13090518 | 0.75 | AKR1B1 (0.37) | AKR1B1MAPTS100A4TRPV1ALDH1A1 | |
| SCHEMBL1119381 | 0.74 | CYP11B1 (0.54) | AKR1B1MAPTS100A4TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501772-B2 | 3,8-diaminotetrahydroquinoline derivative | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2013-08-06 | — | — | US | disclosed |
| US-20130012537-A1 | 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012537-A1 | 3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE | MC2R, GHRHR, REN | AKR1B1 83/4885MAPT 4084/4885GALR3 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.