SCHEMBL1455920

SCHEMBL1455920

CCOC(=O)C(CS)NC(=O)OC(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.61
CYP2C9 P11712 1/20 0.61
CYP2C19 P33261 1/20 0.61
HTT P42858 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.52
ALDH1A1 P00352 3/20 0.49
MAPT P10636 3/20 0.49
CTSK P43235 6/20 0.47
CTSS P25774 4/20 0.47
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
PKM P14618 1/20 0.46
HPGD P15428 1/20 0.46
ALOX12 P18054 1/20 0.46
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
HDAC4 P56524 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1455923 1.00 CYP1A2 (0.61) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL30539270 0.88 CYP1A2 (0.50) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL7079252 0.88 CYP1A2 (0.47) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL6237621 0.88 CYP1A2 (0.47) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL16288581 0.88 CYP1A2 (0.50) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL16288582 0.88 CYP1A2 (0.50) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL6446074 0.87 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL6446073 0.87 CYP1A2 (0.58) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL1341495 0.86 CYP1A2 (0.46) CYP1A2CYP2C9CYP2C19HTTCTSK
SCHEMBL12071191 0.86 CYP1A2 (0.64) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3280717-A1 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS Anacor Pharmaceuticals, Inc. (US) 2018-02-14 EP disclosed
WO-2016164814-A1 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2016-10-13 WO disclosed
EP-1757609-B1 NOVEL WATER-SOLUBLE PRODRUG CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-10-16 EP disclosed
US-8022047-B2 Combination anticancer agents CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2011-09-20 US disclosed
US-7910593-B2 Water-soluble prodrugs CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2011-03-22 US disclosed
US-20100222546-A1 METHODS FOR THE PREPARATION OF FUNCTIONALIZED PEPTIDES, PROTEINS AND CARBOHYDRATES AND THEIR CONJUGATES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-09-02 US disclosed
US-20100222546-A1 METHODS FOR THE PREPARATION OF FUNCTIONALIZED PEPTIDES, PROTEINS AND CARBOHYDRATES AND THEIR CONJUGATES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-09-02 US disclosed
US-20100222549-A1 DECHALCOGENATIVE METHODS FOR THE PREPARATION OF ALLYLIC SULFIDES NIH-DEITR 2010-09-02 US disclosed
US-20090149478-A1 NOVEL COMBINATION ANTICANCER AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA 2009-06-11 US disclosed
US-20090118271-A1 Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2009-05-07 US disclosed
EP-1938823-A1 AGENT FOR PREVENTING OR TREATING PANCREAS CANCER, OVARY CANCER OR LIVER CANCER CONTAINING NOVEL WATER-SOLUBLE PRODRUG CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2008-07-02 EP disclosed
EP-1925309-A1 NOVEL ANTICANCER CONCOMITANT DRUG CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2008-05-28 EP disclosed
US-20080015157-A1 Novel Water-Soluble Prodrugs CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2008-01-17 US disclosed
EP-1757609-A1 NOVEL WATER-SOLUBLE PRODRUG CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2007-02-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149478-A1 NOVEL COMBINATION ANTICANCER AGENTS KRAS, TOP1, ERBB3 CYP1A2 3036/4885CYP2C9 3689/4885CYP2C19 3880/4885
US-20080015157-A1 Novel Water-Soluble Prodrugs ADH1A, ADH1C, SLC43A1 CYP1A2 118/4885CYP2C9 135/4885CYP2C19 158/4885
US-20100222549-A1 DECHALCOGENATIVE METHODS FOR THE PREPARATION OF ALLYLIC SULFIDES TST, SCLY, AP2S1 CYP1A2 634/4885CYP2C9 1081/4885CYP2C19 1077/4885
US-20100222546-A1 METHODS FOR THE PREPARATION OF FUNCTIONALIZED PEPTIDES, PROTEINS AND CARBOHYDRATES AND THEIR CONJUGATES PTMS, STT3A, GCG CYP1A2 4285/4885CYP2C9 3685/4885CYP2C19 3944/4885
US-20090118271-A1 Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug TP53, SLC10A1, BRCA1 CYP1A2 1840/4885CYP2C9 2083/4885CYP2C19 2721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.