Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.65 |
| ▸ | MAOB | P27338 | 4/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.64 |
| ▸ | MITF | O75030 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MYC | P01106 | 2/20 | 0.52 |
| ▸ | MAX | P61244 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20869643 | 0.86 | CISD1 (0.68) | MAOAMAOBCISD1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14527005 | 0.85 | ALDH1A1 (0.67) | MAOAMAOBCISD1ALDH1A1AKR1B1 | |
| SCHEMBL14560452 | 0.84 | MAPT (0.66) | CISD1SMN1; SMN2ALDH1A1POLBMAPK1 | |
| SCHEMBL14900942 | 0.84 | SMN1; SMN2 (0.64) | MAOAMAOBCISD1MITFRAB9A | |
| SCHEMBL13446896 | 0.83 | MMP1 (0.73) | MAOAMAOBCISD1MITFRAB9A | |
| SCHEMBL15816747 | 0.82 | MAOA (0.69) | MAOAMAOBCISD1MITFAKR1B1 | |
| SCHEMBL15816744 | 0.82 | MAOA (0.69) | MAOAMAOBCISD1MITFAKR1B1 | |
| SCHEMBL15816745 | 0.82 | MAOA (0.69) | MAOAMAOBCISD1MITFAKR1B1 | |
| SCHEMBL17295616 | 0.82 | LMNA (0.75) | SMN1; SMN2LMNAHPGD | |
| SCHEMBL17295612 | 0.82 | LMNA (0.75) | SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192967-B1 | Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents | ASTELLAS PHARMA GMBH (DE) | 2007-03-20 | — | — | US | disclosed |