Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CTSG | P08311 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565729 | 0.82 | PKM (0.46) | KDM4EMEN1KMT2A | |
| SCHEMBL14565739 | 0.81 | GPBAR1 (0.56) | POLBTSHRMAPK1MEN1KMT2A | |
| SCHEMBL5444937 | 0.80 | KDM4E (0.52) | RAB9AKDM4EPOLBVCAM1NPBWR1 | |
| SCHEMBL14565751 | 0.75 | TSHR (0.36) | POLBTSHRMAPK1MEN1KMT2A | |
| SCHEMBL14565738 | 0.74 | KMT2A (0.48) | TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL494192 | 0.74 | KDM4E (0.74) | RAB9AKDM4EPOLBVCAM1NPBWR1 | |
| SCHEMBL14565744 | 0.74 | PKM (0.49) | RAB9AKDM4EPOLBTSHRMAPK1 | |
| SCHEMBL14565752 | 0.73 | POLB (0.37) | KDM4EPOLBTSHRMAPK1MEN1 | |
| SCHEMBL14565734 | 0.73 | CTSK (0.49) | — | |
| SCHEMBL14565743 | 0.73 | MEN1 (0.55) | TSHRHCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |