Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565729 | 0.81 | PKM (0.46) | PKMMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5446827 | 0.79 | PKM (0.55) | PKMMEN1KMT2AMAPK1TSHR | |
| SCHEMBL14565745 | 0.78 | CCND1 (0.35) | MEN1KMT2AMAPK1TSHRHPGD | |
| SCHEMBL14565738 | 0.78 | KMT2A (0.48) | MEN1KMT2ATSHREPHX2ALDH1A1 | |
| SCHEMBL7428434 | 0.78 | MEN1 (0.48) | PKMMEN1KMT2AKDM4EPOLB | |
| SCHEMBL7427117 | 0.77 | MEN1 (0.52) | MEN1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL7428439 | 0.76 | MEN1 (0.48) | PKMMEN1KMT2AKDM4EPOLB | |
| SCHEMBL14565743 | 0.76 | MEN1 (0.55) | MEN1KMT2ATSHREPHX2 | |
| SCHEMBL14565734 | 0.76 | CTSK (0.49) | PKM | |
| SCHEMBL14565751 | 0.76 | TSHR (0.36) | MEN1KMT2AMAPK1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |