Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | FABP6 | P51161 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565752 | 0.86 | POLB (0.37) | TSHRALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL14565729 | 0.79 | PKM (0.46) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL7481686 | 0.78 | TSHR (0.36) | TSHRCTSKFABP6ALDH1A1MAPK1 | |
| SCHEMBL14565738 | 0.76 | KMT2A (0.48) | TSHRALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL14565744 | 0.76 | PKM (0.49) | TSHRALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL14562803 | 0.75 | KAT2B (0.32) | — | |
| SCHEMBL14565739 | 0.75 | GPBAR1 (0.56) | TSHRALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL14565737 | 0.75 | RAB9A (0.47) | TSHRMAPK1POLBMEN1KMT2A | |
| SCHEMBL14565734 | 0.75 | CTSK (0.49) | CTSK | |
| SCHEMBL14565745 | 0.75 | CCND1 (0.35) | TSHRCTSKALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |