Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565508 | 0.76 | SMN1; SMN2 (0.54) | NPC1SMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL5534265 | 0.76 | SMN1; SMN2 (0.54) | NPC1SMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL758574 | 0.72 | MAOA (0.47) | RAB9ANPC1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL983160 | 0.71 | PLAU (0.37) | RAB9ANPC1SMN1; SMN2KMT2APOLB | |
| SCHEMBL427374 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBKDM4EHSD17B10LMNA | |
| SCHEMBL5536914 | 0.70 | L3MBTL1 (0.46) | RAB9ANPC1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL1600624 | 0.70 | OPRK1 (0.42) | SMN1; SMN2CYP1A2HSD17B10MAOBMAPK1 | |
| SCHEMBL4482054 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBKDM4EHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL21457860 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1POLBKDM4E | |
| SCHEMBL30036961 | 0.70 | CASP1 (0.49) | KMT2AMEN1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186716-B2 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors | SUGEN, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186716-B2 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors | SUGEN, INC. (US) | 2007-03-06 | — | — | US | disclosed |