Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427374 | 0.84 | SMN1; SMN2 (0.46) | PLAUALDH1A1POLBHCAR2KDM4E | |
| SCHEMBL4492180 | 0.82 | CASP1 (0.49) | PLAUKDM4EHTTKMT2AMAPT | |
| SCHEMBL4482054 | 0.82 | SMN1; SMN2 (0.44) | PLAUALDH1A1POLBHCAR2KDM4E | |
| SCHEMBL30036961 | 0.82 | CASP1 (0.49) | PLAUKDM4EHTTKMT2AMAPT | |
| SCHEMBL1600624 | 0.82 | OPRK1 (0.42) | PLAUALDH1A1KDRHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21457860 | 0.82 | SMN1; SMN2 (0.44) | PLAUALDH1A1POLBHCAR2KDM4E | |
| SCHEMBL4482052 | 0.81 | CSNK2A1 (0.35) | PLAUALDH1A1POLBHCAR2KDM4E | |
| SCHEMBL1160933 | 0.79 | HCAR2 (0.36) | PLAUALDH1A1HCAR2KDRHTT | |
| SCHEMBL29608609 | 0.79 | HCAR2 (0.36) | PLAUALDH1A1HCAR2KDRHTT | |
| SCHEMBL21815554 | 0.78 | ALDH1A1 (0.35) | PLAUALDH1A1POLBHCAR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12421226-B2 | Heteroaryl compounds as necrosis inhibitors, composition and method using the same | ACCRO BIOSCIENCE (HK) LIMITED (HK) | 2025-09-23 | — | — | US | disclosed |
| WO-2025007784-A1 | HETEROAROMATIC RING COMPOUND, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2025-01-09 | — | — | WO | disclosed |
| US-11629132-B2 | Compounds for inducing proliferation and differentiation of cells, and methods of use thereof | THE BROAD INSTITUTE, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| CN-110049975-B | Process for the preparation of 5- (1-phenyl-1H-pyrazol-4-yl) nicotinamide derivatives | 拜耳作物科学股份公司 | 2023-01-31 | — | — | CN | disclosed |
| US-20220112188-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | ACCRO BIOSCIENCE (HK) LIMITED (HK) | 2022-04-14 | — | — | US | disclosed |
| EP-3908277-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | Zhang, Xiaohu (CN) | 2021-11-17 | — | — | EP | disclosed |
| US-10981888-B2 | Preparation method for tricyclic compounds | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| WO-2020146858-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | ACCRO BIOSCIENCE INC. (KY) | 2020-07-16 | — | — | WO | disclosed |
| WO-2020146858-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | ACCRO BIOSCIENCE INC. (KY) | 2020-07-16 | — | — | WO | disclosed |
| US-20190315707-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUNDS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-10-17 | — | — | US | disclosed |
| WO-2004026875-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2004-04-01 | — | — | WO | disclosed |
| US-6706706-B2 | FOR PREVENTING PERINATAL TRANSMISSION OF HIV-1 FROM MOTHER TO BABY AND TREATING HIV INFECTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-03-16 | — | — | US | disclosed |
| US-20030195197-A1 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2003-10-16 | — | — | US | disclosed |
| WO-2003080612-A1 | DIPYRIDODIAZEPINONES AS REVERSE TRANSCRIPTASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2003-10-02 | — | — | WO | disclosed |
| CN-1436189-A | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-08-13 | — | — | CN | disclosed |
| EP-1294720-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2003-03-26 | — | — | EP | disclosed |
| US-6420359-B1 | 5,11-Dihydro-11-ethyl-5-methyl-8-(2-((1-oxido-4-quinolinyl)oxy)ethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one for example; antiviral agents for HIV infection | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2002-07-16 | — | — | US | disclosed |
| US-20020028807-A1 | Non-nucleoside reverse transcriptase inhibitors | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2002-03-07 | — | — | US | disclosed |
| WO-2001096338-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-12-20 | — | — | WO | disclosed |
| US-5034531-A | Viricides | SCHERING CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12421226-B2 | Heteroaryl compounds as necrosis inhibitors, composition and method using the same | TNF, LITAF, PNLIP | PLAU 1430/4885ALDH1A1 2865/4885POLB 951/4885 |
| US-20030195197-A1 | Non-nucleoside reverse transcriptase inhibitors | RCOR1, POLR2H, CCR4 | PLAU 4524/4885ALDH1A1 527/4885POLB 72/4885 |
| US-11629132-B2 | Compounds for inducing proliferation and differentiation of cells, and methods of use thereof | MKI67, MCL1, CD14 | PLAU 1736/4885ALDH1A1 638/4885POLB 2907/4885 |
| US-10981888-B2 | Preparation method for tricyclic compounds | CYP4B1, CYP3A4, CYP1A1 | PLAU 2905/4885ALDH1A1 310/4885POLB 724/4885 |
| US-20190315707-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUNDS | CYP4B1, CYP3A4, CYP1A1 | PLAU 2905/4885ALDH1A1 310/4885POLB 724/4885 |
| US-20220112188-A1 | HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME | TNF, LITAF, PNLIP | PLAU 1430/4885ALDH1A1 2865/4885POLB 951/4885 |
| US-20020028807-A1 | Non-nucleoside reverse transcriptase inhibitors | REV1, POLR2H, POLR2E | PLAU 4312/4885ALDH1A1 1770/4885POLB 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.