Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.66 |
| ▸ | CDK2 | P24941 | 8/20 | 0.66 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14587747 | 0.91 | CDK1 (0.58) | TDP1CCNE1CDK2CCNE2CDK5 | |
| Myoseverin SCHEMBL13325947 | 0.83 | TDP1 (1.00) | TDP1CCNE1CDK2CCNE2CDK5 | |
| Myoseverin SCHEMBL29376276 | 0.83 | TDP1 (1.00) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL13359693 | 0.78 | TDP1 (0.90) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL5461238 | 0.78 | TDP1 (0.86) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL5468119 | 0.76 | TDP1 (0.71) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL14587794 | 0.74 | TDP1 (0.78) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL29949486 | 0.74 | CCNE1 (0.98) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL1443236 | 0.73 | TDP1 (0.80) | TDP1CCNE1CDK2CCNE2CDK5 | |
| SCHEMBL4422862 | 0.73 | CDK1 (0.81) | TDP1CCNE1CDK2CCNE2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |