Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | NAMPT | P43490 | 9/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR1D | P28221 | 4/20 | 0.50 |
| ▸ | HTR1B | P28222 | 4/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690289 | 0.85 | TMEM97 (0.53) | RAB9ANPC1TMEM97SIGMAR1SMN1; SMN2 | |
| SCHEMBL4806699 | 0.78 | ALDH1A1 (0.54) | RAB9ANPC1HTR1BRAD52L3MBTL1 | |
| SCHEMBL14596986 | 0.77 | HTR1A (0.60) | RAB9ANPC1NAMPTHTR1AHTR1D | |
| SCHEMBL5446306 | 0.75 | TMEM97 (0.67) | RAB9ANPC1HTR1AHTR1DHTR1B | |
| SCHEMBL6569460 | 0.75 | GAA (0.49) | RAB9ANPC1HTR1BRAD52L3MBTL1 | |
| SCHEMBL8023505 | 0.75 | MAOA (0.49) | HTR1AHTR1DHTR1BTMEM97SIGMAR1 | |
| SCHEMBL14596985 | 0.74 | HTR1A (0.56) | RAB9ANPC1NAMPTHTR1AHTR1D | |
| SCHEMBL14263999 | 0.73 | HTR1B (0.73) | RAB9ANPC1HTR1BRAD52L3MBTL1 | |
| SCHEMBL14370170 | 0.73 | HTR1B (0.73) | RAB9ANPC1HTR1BRAD52L3MBTL1 | |
| SCHEMBL5354642 | 0.73 | HTR1B (0.73) | RAB9ANPC1HTR1BRAD52L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | HTR1B, HTR1D, HTR1A | RAB9A 838/4885NPC1 1664/4885NAMPT 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.