Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.52 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14596904 | 0.85 | RAB9A (0.58) | TMEM97SIGMAR1ALDH1A1NPC1RAB9A | |
| SCHEMBL5690532 | 0.84 | TMEM97 (0.56) | TMEM97SIGMAR1CXCR3ALDH1A1HPGD | |
| SCHEMBL5446306 | 0.78 | TMEM97 (0.67) | TMEM97SIGMAR1CXCR3NPC1RAB9A | |
| SCHEMBL8023505 | 0.77 | MAOA (0.49) | TMEM97SIGMAR1PIK3CAPIK3CDAKT1 | |
| SCHEMBL14571502 | 0.76 | CXCR3 (0.55) | TMEM97SIGMAR1CXCR3MTHFD2ALDH1A1 | |
| SCHEMBL6820453 | 0.76 | DRD2 (0.50) | PIK3CAPIK3CDAKT1PIK3CBPIK3CG | |
| SCHEMBL7024053 | 0.76 | DRD2 (0.50) | PIK3CAPIK3CDAKT1PIK3CBPIK3CG | |
| SCHEMBL3830330 | 0.76 | DRD2 (0.50) | PIK3CAPIK3CDAKT1PIK3CBPIK3CG | |
| SCHEMBL7023935 | 0.74 | KCNH2 (0.48) | HRH3KMT2AMEN1CYP2C19 | |
| SCHEMBL7024691 | 0.74 | KCNH2 (0.48) | HRH3KMT2AMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101881-B2 | Tetrahydroquinolines | PFIZER INC (US) | 2006-09-05 | — | — | US | claimed |
| EP-1641760-A2 | NOVEL TETRAHYDROQUINOLINES | Pfizer Products Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2004108682-A2 | TETRAHYDROISOQUINOLINES AS ANTAGONISTS OF THE 5HT1B RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-12-16 | — | — | WO | claimed |
| US-20040254193-A1 | Novel tetrahydroquinolines | PFIZER INC | 2004-12-16 | — | — | US | claimed |
| US-7101881-B2 | Tetrahydroquinolines | PFIZER INC (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1641760-A2 | NOVEL TETRAHYDROQUINOLINES | Pfizer Products Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004108682-A2 | TETRAHYDROISOQUINOLINES AS ANTAGONISTS OF THE 5HT1B RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-12-16 | — | — | WO | disclosed |
| US-20040254193-A1 | Novel tetrahydroquinolines | PFIZER INC | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254193-A1 | Novel tetrahydroquinolines | HTR5A, SLC18A2, HTR3B | TMEM97 264/4885SIGMAR1 545/4885CXCR3 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.