Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | IAPP | P10997 | 3/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441467 | 0.84 | NOTUM (0.48) | CYP4F2CYP4A11ALDH1A1GAAPTGER1 | |
| SCHEMBL12802220 | 0.81 | CYP4F2 (0.40) | CYP4F2CYP4A11THRBTHRAALDH1A1 | |
| SCHEMBL9308692 | 0.81 | TAAR1 (0.47) | TSHRIAPP | |
| SCHEMBL14613770 | 0.80 | LPAR1 (0.38) | THRBTHRAGABRA1GABRB2LMNA | |
| SCHEMBL4423947 | 0.80 | MTNR1A (0.53) | THRBTHRATSHRLMNA | |
| SCHEMBL9651251 | 0.79 | IAPP (0.37) | CYP4F2CYP4A11THRBTHRAALDH1A1 | |
| SCHEMBL4601493 | 0.77 | ALDH1A1 (0.46) | CYP4F2CYP4A11ALDH1A1HDAC3HDAC4 | |
| SCHEMBL27405468 | 0.77 | PTGER4 (0.54) | HDAC3HDAC1HDAC2HDAC6LMNA | |
| SCHEMBL28769711 | 0.77 | THRA (0.45) | CYP4F2CYP4A11THRBTHRATSHR | |
| SCHEMBL878984 | 0.76 | KEAP1 (0.56) | CYP4F2CYP4A11HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315750-B1 | CYCLIC PEPTIDES HAVING MELANOCORTIN-4 RECEPTOR AGONIST ACTIVITY | HOFFMANN LA ROCHE (CH) | 2007-02-14 | — | — | EP | disclosed |