SCHEMBL146227

SCHEMBL146227

C=CC(=O)Oc1ccccc1SCC

nearest known ligand 0.55

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 18/20 0.55
THRB P10828 2/20 0.52
THRA P10827 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30747872 1.00 PTGS2 (0.55) PTGS2THRBTHRA
SCHEMBL8650686 0.82 PTGS2 (0.54) PTGS2THRBTHRA
SCHEMBL27594054 0.82 THRB (0.48) PTGS2THRBTHRA
SCHEMBL146547 0.79 PTGS2 (0.56) PTGS2
SCHEMBL30747871 0.79 PTGS2 (0.56) PTGS2
SCHEMBL27594057 0.79 THRB (0.46) PTGS2THRBTHRA
SCHEMBL3841280 0.77 THRB (0.56) THRBTHRA
SCHEMBL29413361 0.77 THRB (0.56) THRBTHRA
SCHEMBL146450 0.77 THRB (0.70) PTGS2THRBTHRA
SCHEMBL20556099 0.76 KDM4E (0.46) PTGS2THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023218463-A1 RADIATION INDUCED RADICAL CURING BY SEMICONDUCTING NANOPARTICLES YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2023-11-16 WO claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE 2018-12-06 US claimed
EP-2292672-B1 Biocompatible polymers and co-polymers comprising amino acids in the side chain CIS PHARMA AG (CH) 2018-05-09 EP claimed
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof HITZ HANS (CH) 2017-06-01 US claimed
EP-1888660-B1 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CIS PHARMA AG (CH) 2017-05-17 EP claimed
US-8980957-B2 Methods for the preparation of biocompatible polymers, the polymers and their uses CIS PHARMA AG (CH) 2015-03-17 US claimed
US-20140242722-A1 ARTICLE AND METHOD FOR DETECTION OF A DRUG IN A LIQUID MEDIUM MEDTECH DETECT, LLC (US) 2014-08-28 US claimed
WO-2014062910-A1 SPIROPYRAN-BASED COLORIMETRIC DETECTION MEDTECH DETECT, LLC (US) 2014-04-24 WO claimed
US-20130158161-A1 Polycarbonate Resin Composition with Mar Resistance and Scratch Resistance CHEIL INDUSTRIES INC. (KR) 2013-06-20 US claimed
EP-1664855-B1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB (US) 2009-03-11 EP claimed
EP-1888660-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN Chemisches Institut Schaefer AG (CH) 2008-02-20 EP claimed
US-7276544-B2 Process for manufacturing intraocular lenses with blue light absorption characteristics BAUSCH & LOMB INCORPORATED (US) 2007-10-02 US claimed
WO-2006126095-A2 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN CHEMISCHES INSTITUT SCHAEFER AG (CH) 2006-11-30 WO claimed
EP-1664855-A1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB INCORPORATED (US) 2006-06-07 EP claimed
WO-2005026787-A1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB INCORPORATED (US) 2005-03-24 WO claimed
US-20050055090-A1 Process for manufacturing intraocular lenses with blue light absorption characteristics BAUSCH HEALTH US, LLC 2005-03-10 US claimed
US-6353069-B1 INTRAOCULAR LENSES THAT HAVE HIGH REFRACTIVE INDEXES, ARE FLEXIBLE AND TRANSPARENT, CAN BE INSERTED INTO EYE THROUGH RELATIVELY SMALL INCISION, RECOVER ORIGINAL SHAPE AFTER HAVING BEEN INSERTED, AND ARE FREE OF GLISTENINGS ALCON MANUFACTURING, LTD. 2002-03-05 US claimed
EP-1080382-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS Alcon Laboratories, Inc. (US) 2001-03-07 EP claimed
WO-1999053347-A1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON LABORATORIES, INC. (US) 1999-10-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170152335-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 PTGS2 880/4885THRB 4338/4885THRA 3671/4885
US-20180346629-A1 Biocompatible polymers and co-polymers, and uses thereof ARG1, CRYAA, COL1A1 PTGS2 880/4885THRB 4338/4885THRA 3671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.