Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463332 | 0.86 | MAPT (0.42) | GPR119TP53MAPTGPR35GPR55 | |
| SCHEMBL74671 | 0.85 | POLB (0.45) | GPR119TP53MAPTGPR35GPR55 | |
| SCHEMBL2682211 | 0.84 | GPR119 (0.44) | GPR119TP53MAPTRORCHDAC4 | |
| SCHEMBL432167 | 0.82 | TRPV1 (0.40) | GPR119TRPV1MEN1KMT2A | |
| SCHEMBL1726705 | 0.81 | SLC6A3 (0.42) | MAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1462886 | 0.78 | SLC6A3 (0.40) | — | |
| SCHEMBL1727318 | 0.78 | MCHR1 (0.44) | — | |
| SCHEMBL4184500 | 0.77 | DYRK2 (0.41) | GPR119TP53MAPTCCR8 | |
| SCHEMBL2680949 | 0.77 | F10 (0.42) | MEN1KMT2A | |
| SCHEMBL1420945 | 0.77 | MCHR1 (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-07 | — | — | US | disclosed |
| US-9808006-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-11-07 | — | — | US | disclosed |
| EP-2451801-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-28 | — | — | US | disclosed |
| US-8586593-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-8518971-B2 | Insecticidal phenyl- or pyridyl-piperdine compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-8193362-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-06-05 | — | — | US | disclosed |
| WO-2012037282-A3 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120115884-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2012-05-10 | — | — | US | disclosed |
| EP-2297136-B1 | INSECTICIDAL PYRIDYLPIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2324010-B1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110071191-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | ACHE, CHRM1, CHRM2 | GPR119 373/4885TP53 4421/4885IDH1 2735/4885 |
| US-20120115884-A1 | INSECTICIDAL COMPOUNDS | ACHE, C1R, C5 | GPR119 495/4885TP53 4671/4885IDH1 2610/4885 |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GPR119 373/4885TP53 4421/4885IDH1 2735/4885 |
| US-20110071191-A1 | INSECTICIDAL COMPOUNDS | CBR3, CBR1, ACHE | GPR119 838/4885TP53 4690/4885IDH1 1187/4885 |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GPR119 515/4885TP53 4524/4885IDH1 2964/4885 |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GPR119 373/4885TP53 4421/4885IDH1 2735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.