SCHEMBL14645844

SCHEMBL14645844

COC(=O)c1cc(C#N)cc(C)c1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.49
KDM4E B2RXH2 8/20 0.49
HPGD P15428 4/20 0.49
POLB P06746 1/20 0.44
GAA P10253 5/20 0.42
CISD2 Q8N5K1 1/20 0.40
HSD17B10 Q99714 3/20 0.39
MAPT P10636 3/20 0.39
GLA P06280 1/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
ATM Q13315 1/20 0.39
LMNA P02545 1/20 0.39
CFTR P13569 1/20 0.39
ABL1 P00519 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
GPR35 Q9HC97 1/20 0.38
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12326381 0.84 KDM4E (0.51) ALDH1A1KDM4EPOLBGAAHSD17B10
SCHEMBL15733279 0.84 KDM4E (0.45) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL28853045 0.83 KDM4E (0.36) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL15733357 0.83 ADORA2A (0.46) ALDH1A1KDM4EHPGDGAACISD2
SCHEMBL16411023 0.83 KDM4E (0.54) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL19783127 0.83 KDM4E (0.44) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL16411014 0.83 KDM4E (0.44) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL14397086 0.82 KDM4E (0.43) ALDH1A1KDM4EHPGDPOLBGAA
SCHEMBL951068 0.81 KDM4E (0.59) KDM4EGPR35
SCHEMBL21990971 0.81 KDM4E (0.42) ALDH1A1KDM4EHPGDGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024176261-A1 A PROCESS FOR PREPARATION OF ANTHRANILAMIDE COMPOUND AND INTERMEDIATE THEREOF UPL LIMITED (IN) 2024-08-29 WO disclosed
US-20240067624-A1 PROCESS FOR PREPARATION OF INSECTICIDAL ANTHRANILAMIDES UPL LTD (IN) 2024-02-29 US disclosed
US-20240067624-A1 PROCESS FOR PREPARATION OF INSECTICIDAL ANTHRANILAMIDES UPL LTD (IN) 2024-02-29 US disclosed
US-20240067624-A1 PROCESS FOR PREPARATION OF INSECTICIDAL ANTHRANILAMIDES UPL LTD (IN) 2024-02-29 US disclosed
CN-116496460-B Covalent organic framework material, ligand and application thereof 吉林省卓材新研科技有限公司 2023-10-20 CN disclosed
CN-116730977-A Novel aryl heterocyclic compound, and preparation method and application thereof 华东理工大学 2023-09-12 CN disclosed
CN-116724015-A Process for preparing insecticidal anthranilamides UPL有限公司 2023-09-08 CN disclosed
CN-116496460-A Covalent organic framework material, ligand and application thereof 吉林省卓材新研科技有限公司 2023-07-28 CN disclosed
US-20230088326-A1 PROCESS FOR PREPARATION OF ARTHROPODICIDAL ANTHRANILAMIDE COMPOUNDS UPL LTD (IN) 2023-03-23 US disclosed
CN-115279746-A Process for preparing arthropodicidal anthranilamide compounds UPL有限公司 2022-11-01 CN disclosed
EP-2729462-B1 METHOD FOR MANUFACTURING TETRAZOLE SUBSTITUTED ANTHRANILIC ACID DERIVATIVES BY CONVERTING PYRAZOLE ACIDS WITH ANTHRANILIC ACID ESTERS BAYER IP GMBH (DE) 2017-10-04 EP disclosed
EP-2729444-B1 METHOD FOR MANUFACTURING 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE BAYER IP GMBH (DE) 2017-08-23 EP disclosed
US-9169198-B2 Method for the production of 2-amino-5-cyano-N,3-dimethylbenzamide BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-10-27 US disclosed
US-8916710-B2 Method for producing tetrazole-substituted anthranilic acid diamide derivatives by reacting pyrazolic acids with anthranilic acid esters BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-12-23 US disclosed
US-20140235865-A1 METHOD FOR PRODUCING TETRAZOLE-SUBSTITUTED ANTHRANILIC ACID DIAMIDE DERIVATIVES BY REACTING PYRAZOLIC ACIDS WITH ANTHRANILIC ACID ESTERS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-08-21 US disclosed
US-20140148611-A1 METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-05-29 US disclosed
EP-2729462-A1 METHOD FOR PRODUCING TETRAZOLE-SUBSTITUTED ANTHRANILIC ACID DIAMIDE DERIVATIVES BY REACTING PYRAZOLIC ACIDS WITH ANTHRANILIC ACID ESTERS Bayer Intellectual Property GmbH (DE) 2014-05-14 EP disclosed
EP-2729444-A1 METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE Bayer Intellectual Property GmbH (DE) 2014-05-14 EP disclosed
WO-2013007604-A1 METHOD FOR PRODUCING TETRAZOLE-SUBSTITUTED ANTHRANILIC ACID DIAMIDE DERIVATIVES BY REACTING PYRAZOLIC ACIDS WITH ANTHRANILIC ACID ESTERS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-01-17 WO disclosed
WO-2013007603-A1 METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148611-A1 METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE ALKBH5, ALKBH2, MMAB ALDH1A1 1505/4885KDM4E 124/4885HPGD 858/4885
US-20240067624-A1 PROCESS FOR PREPARATION OF INSECTICIDAL ANTHRANILAMIDES ANTXR2, NAAA, AGPS ALDH1A1 1498/4885KDM4E 1624/4885HPGD 442/4885
US-20230088326-A1 PROCESS FOR PREPARATION OF ARTHROPODICIDAL ANTHRANILAMIDE COMPOUNDS ANTXR2, APEH, TYR ALDH1A1 1202/4885KDM4E 1445/4885HPGD 686/4885
US-20140235865-A1 METHOD FOR PRODUCING TETRAZOLE-SUBSTITUTED ANTHRANILIC ACID DIAMIDE DERIVATIVES BY REACTING PYRAZOLIC ACIDS WITH ANTHRANILIC ACID ESTERS DAO, QPCT, AADAT ALDH1A1 969/4885KDM4E 1968/4885HPGD 1223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.