SCHEMBL14645967

SCHEMBL14645967

CC1=Cc2c(cc(C(C)(C)C)cc2-c2ccccc2)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
NPC1 O15118 1/20 0.33
PLA2G1B P04054 1/20 0.33
NFKB1 P19838 1/20 0.33
CASP3 P42574 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
CYP19A1 P11511 1/20 0.33
RXRA P19793 1/20 0.33
RXRB P28702 1/20 0.33
ELANE P08246 1/20 0.32
CD69 Q07108 1/20 0.32
ESR2 Q92731 1/20 0.31
SQOR Q9Y6N5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29949127 1.00 ALDH1A1 (0.33) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL4203318 0.80 PSMB5 (0.38) ALDH1A1ESR2MAPT
SCHEMBL4198077 0.80 TSHR (0.37) ALDH1A1NPC1RAB9ARXRARXRB
SCHEMBL2962655 0.78 AKR1C3 (0.38) ALDH1A1NPC1RAB9AESR2
SCHEMBL2482030 0.78 DHODH (0.37) ESR2MAPT
SCHEMBL14645972 0.77 NPC1 (0.33) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL4653379 0.75 METAP2 (0.41) ESR2MAPT
SCHEMBL29594786 0.75 RXRB (0.36) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL6031753 0.75 RXRB (0.36) ALDH1A1NPC1PLA2G1BNFKB1CASP3
SCHEMBL28251447 0.75 NPC1 (0.33) ALDH1A1NPC1PLA2G1BNFKB1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209127-A1 NEW METALLOCENE CATALYST AND USE THEREOF TOTALENERGIES ONETECH BELGIUM (BE) 2024-06-27 US disclosed
EP-4347667-A1 NEW METALLOCENE CATALYST AND USE THEREOF TotalEnergies OneTech Belgium (BE) 2024-04-10 EP disclosed
CN-117396523-A Novel metallocene catalysts and their use 道达尔能源一技术比利时公司 2024-01-12 CN disclosed
WO-2022248517-A1 NEW METALLOCENE CATALYST AND USE THEREOF TOTALENERGIES ONETECH BELGIUM (BE) 2022-12-01 WO disclosed
EP-2722345-B1 CATALYST FOR THE POLYMERISATION OF OLEFINS BOREALIS AG (AT) 2018-12-05 EP disclosed
EP-2729479-B1 CATALYSTS BOREALIS AG (AT) 2017-09-06 EP disclosed
US-9630980-B2 Asymmetrical ligands BOREALIS AG (AT) 2017-04-25 US disclosed
US-9567351-B2 Heterophasic copolymers BOREALIS AG (AT) 2017-02-14 US disclosed
US-9475890-B2 Catalyst BOREALIS AG (AT) 2016-10-25 US disclosed
US-9469700-B2 Polymerisation process and catalyst BOREALIS AG (AT) 2016-10-18 US disclosed
US-20150259442-A1 POLYMERISATION PROCESS AND CATALYST BOREALIS AG (AT) 2015-09-17 US disclosed
US-20140221584-A1 CATALYSTS BOREALIS AG (AT) 2014-08-07 US disclosed
US-20140206819-A1 HETEROPHASIC COPOLYMERS BOREALIS AG (AT) 2014-07-24 US disclosed
EP-2729479-A1 CATALYSTS Borealis AG (AT) 2014-05-14 EP disclosed
EP-2729529-A1 HETEROPHASIC COPOLYMERS Borealis AG (AT) 2014-05-14 EP disclosed
WO-2014060540-A1 POLYMERISATION PROCESS AND CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
EP-2722345-A1 Catalyst Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722346-A1 Polymerisation process and catalyst Borealis AG (AT) 2014-04-23 EP disclosed
WO-2013007650-A1 CATALYSTS BOREALIS AG (AT) 2013-01-17 WO disclosed
WO-2013007664-A1 HETEROPHASIC COPOLYMERS BOREALIS AG (AT) 2013-01-17 WO disclosed