Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581879 | 0.73 | MEN1 (0.36) | SMN1; SMN2ALDH1A1CYP2C19KDM4EMEN1 | |
| SCHEMBL3437747 | 0.72 | THRA (0.33) | THRATHRBL3MBTL1 | |
| SCHEMBL1464150 | 0.72 | THRA (0.33) | THRATHRBL3MBTL1 | |
| SCHEMBL3986354 | 0.72 | DRD2 (0.38) | THRATHRBALDH1A1MEN1KMT2A | |
| SCHEMBL13963699 | 0.71 | CNR1 (0.47) | SMN1; SMN2ALDH1A1L3MBTL1CYP2C19MEN1 | |
| SCHEMBL3987891 | 0.71 | KMT2A (0.49) | MEN1KMT2AHPGDCCR5 | |
| SCHEMBL5880795 | 0.70 | ALDH1A1 (0.60) | HSD11B1SMN1; SMN2ALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL14596706 | 0.70 | PTGDR (0.35) | SMN1; SMN2ALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL14596420 | 0.70 | GPR4 (0.38) | SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL11880887 | 0.69 | ALDH1A1 (0.63) | HSD11B1SMN1; SMN2ALDH1A1L3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-7807838-B2 | Methods for the preparation of HCV polymerase inhibitors | PFIZER INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807838-B2 | Methods for the preparation of HCV polymerase inhibitors | PFIZER INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807838-B2 | Methods for the preparation of HCV polymerase inhibitors | PFIZER INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090023921-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| US-20090023921-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| US-20090023921-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| EP-1928878-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007023381-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007023381-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023921-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | POLRMT, POLI, POLM | HSD11B1 1373/4885SMN1; SMN2 3321/4885THRA 4557/4885 |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | POLRMT, POLI, POLM | HSD11B1 1373/4885SMN1; SMN2 3321/4885THRA 4557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.