Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890869 | 0.98 | DPP4 (0.48) | DPP4ALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL31193466 | 0.86 | DPP4 (0.60) | DPP4ALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL7820374 | 0.84 | DPP4 (0.48) | DPP4ALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL24456032 | 0.84 | DPP4 (0.54) | DPP4ALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL31258574 | 0.83 | CES2 (0.47) | ALDH1A1KDM4ETP53TSHRCES2 | |
| SCHEMBL365563 | 0.83 | CES2 (0.47) | ALDH1A1KDM4ETP53TSHRCES2 | |
| SCHEMBL1197627 | 0.82 | ALDH1A1 (0.48) | DPP4ALDH1A1RPA1ALOX15CES2 | |
| SCHEMBL9694217 | 0.82 | DPP4 (0.40) | DPP4ALDH1A1TP53RPA1CES2 | |
| SCHEMBL2127072 | 0.81 | DPP4 (0.45) | DPP4ALDH1A1KDM4EHSD17B10TP53 | |
| SCHEMBL24680171 | 0.81 | DPP4 (0.45) | DPP4ALDH1A1KDM4EHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220380346-A1 | 2,3-DIHYDRO-ISOINDOLE-1-ON DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | CRYSTALGENOMICS, INC. (KR) | 2022-12-01 | — | — | US | disclosed |
| EP-3428161-B1 | 2,3-DIHYDRO-ISOINDOLE-1-ONE DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | CRYSTALGENOMICS INC (KR) | 2022-09-07 | — | — | EP | disclosed |
| US-11230539-B2 | 2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same | CRYSTALGENOMICS, INC. (KR) | 2022-01-25 | — | — | US | disclosed |
| US-20210009565-A1 | 2,3-DIHYDRO-ISOINDOLE-1-ONE DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | CRYSTALGENOMICS, INC. (KR) | 2021-01-14 | — | — | US | disclosed |
| US-10604508-B2 | 2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same | CRYSTALGENOMICS, INC. (KR) | 2020-03-31 | — | — | US | disclosed |
| US-10208068-B2 | Macrocycles as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-19 | — | — | US | disclosed |
| EP-3428161-A1 | 2,3-DIHYDRO-ISOINDOLE-1-ON DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Crystalgenomics, Inc. (KR) | 2019-01-16 | — | — | EP | disclosed |
| EP-2940014-B1 | 2,3-DIHYDRO-ISOINDOLE-1-ON DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | CRYSTALGENOMICS INC (KR) | 2018-09-26 | — | — | EP | disclosed |
| US-20180148461-A1 | NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-31 | — | — | US | disclosed |
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |
| EP-1751124-A2 | RAF MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1712550-A2 | Substituted triazole diamine derivatives as kinase inhibitors | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1355889-B1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005112932-A2 | RAF MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050239841-A1 | New compounds | BIOVITRUM AB (SE) | 2005-10-27 | — | — | US | disclosed |
| US-6924323-B2 | Sulfonium salt compound | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | disclosed |
| US-20040033434-A1 | Sulfonium salt compound | FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) | 2004-02-19 | — | — | US | disclosed |
| EP-1314725-A1 | SULFONIUM SALT COMPOUND | Wako Pure Chemical Industries, Ltd. (JP) | 2003-05-28 | — | — | EP | disclosed |
| CN-1152853-A | Fungicidal compositions based on 3-phenylpyrazole derivatives for treating plant propagation material, novel 3-phenylpyrazole derivatives and their fungicidal use | RHONE POULENC AGROCHIMIE (FR) | 1997-06-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148461-A1 | NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F12 | DPP4 1751/4885ALDH1A1 4457/4885KDM4E 824/4885 |
| US-10208068-B2 | Macrocycles as factor XIa inhibitors | TFPI, TFPI2, F12 | DPP4 1277/4885ALDH1A1 4479/4885KDM4E 801/4885 |
| US-11230539-B2 | 2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same | BTK, BRSK2, LCK | DPP4 1854/4885ALDH1A1 2483/4885KDM4E 1519/4885 |
| US-10604508-B2 | 2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same | BTK, LCK, BRSK2 | DPP4 2309/4885ALDH1A1 3104/4885KDM4E 1429/4885 |
| US-20210009565-A1 | 2,3-DIHYDRO-ISOINDOLE-1-ONE DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | BTK, BRSK2, LCK | DPP4 1854/4885ALDH1A1 2483/4885KDM4E 1519/4885 |
| US-20050239841-A1 | New compounds | MCHR1, NPY1R, HCRTR1 | DPP4 3829/4885ALDH1A1 1918/4885KDM4E 3911/4885 |
| US-20220380346-A1 | 2,3-DIHYDRO-ISOINDOLE-1-ON DERIVATIVE AS BTK KINASE SUPPRESSANT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | BTK, LCK, BRSK2 | DPP4 2216/4885ALDH1A1 3265/4885KDM4E 1445/4885 |
| US-20040033434-A1 | Sulfonium salt compound | SPIN1, RER1, SPIN2B | DPP4 3404/4885ALDH1A1 2370/4885KDM4E 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.