SCHEMBL14680932

SCHEMBL14680932

COc1cc(OC(=O)C(C)(C)C)cc(OC(=O)C(C)(C)Br)c1

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ELANE P08246 13/20 0.48
ALDH1A1 P00352 1/20 0.41
BRD4 O60885 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15431761 0.94 ALDH1A1 (0.46) ELANEALDH1A1BRD4
SCHEMBL5597484 0.86 ELANE (0.45) ELANE
SCHEMBL9925703 0.84 ELANE (0.64) ELANE
SCHEMBL21441636 0.81 ELANE (0.45) ELANE
SCHEMBL5161247 0.80 ELANE (0.46) ELANEALDH1A1
SCHEMBL437118 0.79 ELANE (0.53) ELANEALDH1A1
SCHEMBL13873976 0.76 CA1 (0.46) ELANEALDH1A1
SCHEMBL11596680 0.76 ELANE (0.73) ELANE
SCHEMBL809308 0.76 PLA2G2A (0.42) ELANE
SCHEMBL9954037 0.75 ELANE (0.70) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11819531-B2 Multifunctional zwitterionic polymer conjugates KODIAK SCIENCES INC. (US) 2023-11-21 US disclosed
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC. 2023-09-07 US disclosed
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC. 2017-05-25 US disclosed
US-20170007710-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES KODIAK SCIENCES INC. 2017-01-12 US disclosed
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2016-10-06 US disclosed
US-20150004128-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES OLIGASIS, LLC (US) 2015-01-01 US disclosed
US-8765432-B2 Targeted drug phosphorylcholine polymer conjugates OLIGASIS, LLC (US) 2014-07-01 US disclosed
US-20130045522-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES OLIGASIS (US) 2013-02-21 US disclosed
US-20130034517-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES OLIGASIS (US) 2013-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 ELANE 733/4885ALDH1A1 4195/4885BRD4 2678/4885
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 ELANE 733/4885ALDH1A1 4195/4885BRD4 2678/4885
US-20130034517-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES PHOSPHO1, EPHA2, PCTP ELANE 2386/4885ALDH1A1 4156/4885BRD4 1327/4885
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG ELANE 432/4885ALDH1A1 4348/4885BRD4 940/4885
US-20170007710-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES PHOSPHO1, EPHA2, PCTP ELANE 2386/4885ALDH1A1 4156/4885BRD4 1327/4885
US-20150004128-A1 TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES PHOSPHO1, EPHA2, PCTP ELANE 2386/4885ALDH1A1 4156/4885BRD4 1327/4885
US-11819531-B2 Multifunctional zwitterionic polymer conjugates PHOSPHO1, MSN, ZW10 ELANE 733/4885ALDH1A1 4195/4885BRD4 2678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.