Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686151 | 0.83 | ALDH1A1 (0.49) | KMT2AALDH1A1HSP90AB1MEN1LMNA | |
| SCHEMBL3703475 | 0.64 | JAK2 (0.55) | JAK2JAK3 | |
| SCHEMBL7093887 | 0.63 | HSP90AB1 (0.45) | KMT2AALDH1A1HSP90AB1MEN1HTT | |
| SCHEMBL4757863 | 0.63 | NUDT1 (0.35) | JAK2JAK3KMT2AALDH1A1MEN1 | |
| SCHEMBL4760688 | 0.63 | NPC1 (0.41) | JAK2JAK3KMT2AALDH1A1GAA | |
| SCHEMBL5741027 | 0.61 | SMPD3 (0.50) | JAK2JAK3 | |
| SCHEMBL7508654 | 0.61 | MEN1 (0.51) | KMT2AALDH1A1MEN1CYP1A2MAPK1 | |
| SCHEMBL4709570 | 0.61 | KDM4E (0.38) | JAK2JAK3KMT2AALDH1A1MEN1 | |
| SCHEMBL23994765 | 0.60 | ADCY10 (0.38) | KMT2AALDH1A1MEN1CYP1A2HTT | |
| SCHEMBL5453382 | 0.60 | KDM4E (0.37) | JAK2JAK3KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-B1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-13 | — | — | EP | claimed |