Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667087 | 0.85 | MAPT (0.41) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL14693601 | 0.77 | RAB9A (0.45) | MAPTRAB9ANPC1HPGDGFER | |
| SCHEMBL29218170 | 0.75 | FGFR1 (0.53) | MAPTRAB9ANPC1HPGDGFER | |
| SCHEMBL30999883 | 0.72 | FGFR1 (0.50) | MAPTRAB9ANPC1HPGDGFER | |
| SCHEMBL30163022 | 0.68 | NPC1 (0.42) | MAPTRAB9ANPC1CYP2C9MEN1 | |
| SCHEMBL14693559 | 0.68 | MAPK14 (0.44) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11333428 | 0.67 | RAB9A (0.62) | MAPTRAB9ANPC1HPGDGFER | |
| SCHEMBL29366393 | 0.67 | ALDH1A1 (0.51) | MAPTHPGDGFERMEN1KMT2A | |
| SCHEMBL543835 | 0.66 | MAPT (0.56) | MAPTRAB9ANPC1HPGDGFER | |
| SCHEMBL24933448 | 0.65 | SMN1; SMN2 (0.59) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377946-B1 | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS, INC. (US) | 2013-02-19 | — | — | US | disclosed |