Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218170 | 0.84 | FGFR1 (0.53) | NPC1RAB9AFGFR1MAPTCYP2C9 | |
| SCHEMBL24933537 | 0.81 | KMT2A (0.41) | NPC1RAB9ACYP11B2CYP11B1MAPT | |
| SCHEMBL30163006 | 0.74 | GABRP (0.36) | NPC1RAB9AFGFR1P2RX4MAPT | |
| SCHEMBL2677079 | 0.70 | PDE5A (0.44) | KMT2A | |
| SCHEMBL24933525 | 0.70 | RORC (0.33) | — | |
| SCHEMBL8541169 | 0.69 | ALDH1A1 (0.43) | RAB9AFGFR1MAPTCYP19A1CYP2C9 | |
| SCHEMBL24933448 | 0.68 | SMN1; SMN2 (0.59) | NPC1RAB9AFGFR1PDE4APDE4B | |
| SCHEMBL14693420 | 0.68 | MAPT (0.46) | NPC1RAB9AFGFR1MAPTCYP2C9 | |
| SCHEMBL29366393 | 0.68 | ALDH1A1 (0.51) | FGFR1MAPTMEN1KMT2A | |
| SCHEMBL12253490 | 0.66 | NPC1 (0.72) | NPC1RAB9AP2RX4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |