Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14704531 | 0.83 | NOS1 (0.44) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL9350959 | 0.79 | RAD52 (0.66) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL6816554 | 0.77 | NOS1 (0.50) | MAPTKDM4EALDH1A1NOS1BCHE | |
| SCHEMBL6819013 | 0.74 | NOS1 (0.56) | MAPTKDM4EKMT2AALDH1A1LMNA | |
| SCHEMBL3298289 | 0.71 | KCNH3 (0.73) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL7242367 | 0.70 | KMT2A (0.58) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL12175837 | 0.68 | RAD52 (1.00) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL7939004 | 0.66 | APP (0.68) | RAD52MAPTKDM4ENPSR1KMT2A | |
| SCHEMBL28693949 | 0.66 | KMT2A (0.81) | KDM4ENPSR1KMT2AALDH1A1ACHE | |
| SCHEMBL28700972 | 0.66 | CYP1A2 (0.50) | MAPTKDM4EKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739053-B2 | P62-ZZ chemical inhibitor | ID4PHARMA, LLC (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739053-B2 | P62-ZZ chemical inhibitor | ID4PHARMA, LLC (US) | 2023-08-29 | — | — | US | disclosed |
| US-20200031761-A1 | P62-ZZ CHEMICAL INHIBITOR | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2020-01-30 | — | — | US | disclosed |
| US-9580382-B2 | p62-ZZ chemical inhibitor | ID4PHARMA, LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580382-B2 | p62-ZZ chemical inhibitor | ID4PHARMA, LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160031799-A1 | P62-ZZ CHEMICAL INHIBITOR | ID4PHARMA LLC (US) | 2016-02-04 | — | — | US | disclosed |
| US-20160031799-A1 | P62-ZZ CHEMICAL INHIBITOR | ID4PHARMA LLC (US) | 2016-02-04 | — | — | US | disclosed |
| US-20150175607-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150175607-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-06-25 | — | — | US | disclosed |
| WO-2013022919-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2013-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031761-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, CTSZ, BECN1 | RAD52 1983/4885MAPT 318/4885KDM4E 2114/4885 |
| US-20160031799-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, CTSZ, BECN1 | RAD52 1983/4885MAPT 318/4885KDM4E 2114/4885 |
| US-11739053-B2 | P62-ZZ chemical inhibitor | SQSTM1, CTSZ, BECN1 | RAD52 1983/4885MAPT 318/4885KDM4E 2114/4885 |
| US-20150175607-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, CTSZ, BECN1 | RAD52 1983/4885MAPT 318/4885KDM4E 2114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.