SCHEMBL14705997

SCHEMBL14705997

O=C(NC1(c2ncc(Cl)cn2)CC1)OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.47
CTSL P07711 1/20 0.43
CTSB P07858 1/20 0.43
CTSS P25774 1/20 0.43
POLB P06746 2/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
ALDH1A1 P00352 4/20 0.41
LMNA P02545 3/20 0.41
TP53 P04637 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
GAA P10253 1/20 0.40
CCR1 P32246 1/20 0.39
PPARA Q07869 1/20 0.39
MAPT P10636 1/20 0.39
PTPN7 P35236 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31247681 0.81 P2RX7 (0.46) P2RX7CTSLCTSBCTSSPOLB
SCHEMBL16545238 0.79 ALDH1A1 (0.45) P2RX7CTSLCTSBCTSSPOLB
SCHEMBL21760459 0.77 CTSL (0.45) CTSLCTSBCTSSPOLBSMN1; SMN2
SCHEMBL2147641 0.76 CTSL (0.42) P2RX7CTSLCTSBCTSSPOLB
SCHEMBL1015573 0.75 ALDH1A1 (0.39) CTSLCTSBCTSSALDH1A1MEN1
SCHEMBL5097407 0.75 MIF (0.49) CTSLCTSBCTSSPOLBSMN1; SMN2
SCHEMBL19920775 0.75 CTSL (0.46) CTSLCTSBCTSSPOLBSMN1; SMN2
SCHEMBL12461577 0.74 CTSB (0.43) P2RX7CTSLCTSBCTSSPOLB
SCHEMBL22995473 0.73 CTSS (0.44) P2RX7CTSLCTSBCTSSPOLB
SCHEMBL17892948 0.73 PKM (0.45) CTSLCTSBCTSSALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250236612-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2025-07-24 US disclosed
EP-4584258-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2025-07-16 EP disclosed
US-20250161465-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2025-05-22 US disclosed
US-12180193-B2 Accelerating fibrosarcoma protein degrading compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2024-12-31 US disclosed
US-12156916-B2 Rapid accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2024-12-03 US disclosed
US-20240156967-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2024-05-16 US disclosed
US-20240156968-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-05-16 US disclosed
US-11957759-B1 Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2024-04-16 US disclosed
WO-2024054591-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-03-14 WO disclosed
WO-2024054591-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-03-14 WO disclosed
CN-117062814-A Compounds that rapidly accelerate fibrosarcoma protein degradation and related methods of use 阿维纳斯运营公司 2023-11-14 CN disclosed
EP-4204418-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2023-07-05 EP disclosed
US-20230081501-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2023-03-16 US disclosed
WO-2022047145-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2022-03-03 WO disclosed
WO-2022047145-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2022-03-03 WO disclosed
WO-2013020245-A1 CARBONYL DERIVATIVES OF BETULIN GLAXOSMITHKLINE LLC (US) 2013-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230081501-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE CRBN, RBX1, ARAF P2RX7 4670/4885CTSL 2909/4885CTSB 2261/4885
US-12156916-B2 Rapid accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use BRAF, ARAF, RAF1 P2RX7 4862/4885CTSL 2584/4885CTSB 3359/4885
US-12180193-B2 Accelerating fibrosarcoma protein degrading compounds and associated methods of use CRBN, RBX1, ARAF P2RX7 4668/4885CTSL 2948/4885CTSB 2216/4885
US-20240156968-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARAF, BRAF, HRAS P2RX7 4628/4885CTSL 2236/4885CTSB 895/4885
US-20250236612-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE CRBN, RBX1, ARAF P2RX7 4670/4885CTSL 2909/4885CTSB 2261/4885
US-20240156967-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE BRAF, ARAF, RAF1 P2RX7 4861/4885CTSL 2700/4885CTSB 3408/4885
US-20250161465-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARAF, BRAF, HRAS P2RX7 4628/4885CTSL 2236/4885CTSB 895/4885
US-11957759-B1 Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use BRAF, ARAF, RAF1 P2RX7 4859/4885CTSL 2756/4885CTSB 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.