SCHEMBL14713359

SCHEMBL14713359

CC(COC(=O)C(C)(C)Br)COC(=O)C(C)(C)Br

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 1/20 0.38
MAPT P10636 1/20 0.34
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2A Q12879 1/20 0.32
GRIN2B Q13224 1/20 0.32
GRIN2C Q14957 1/20 0.32
GRIN3A Q8TCU5 1/20 0.32
MMP8 P22894 1/20 0.32
TSHR P16473 3/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19452281 0.90 MAPT (0.46) PRKCAMAPTMMP8
SCHEMBL19452182 0.86 TSHR (0.44) PRKCAMMP8TSHRALDH1A1GAA
SCHEMBL19370986 0.83 PRKCA (0.35) PRKCA
SCHEMBL13168170 0.81 PRKCA (0.55) PRKCAMAPTMMP8TSHRPOLB
SCHEMBL2551899 0.81 PRKCA (0.35) PRKCAMAPTALDH1A1
SCHEMBL24179939 0.78 MMP8 (0.38) PRKCAMMP8TSHRALDH1A1GAA
SCHEMBL20149747 0.78 PRKCA (0.44) PRKCA
SCHEMBL20149743 0.78 PRKCA (0.37) PRKCAMAPTMMP8
SCHEMBL28956981 0.77 PRKCA (0.35) PRKCA
SCHEMBL6658363 0.77 ADRB2 (0.36) PRKCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11819531-B2 Multifunctional zwitterionic polymer conjugates KODIAK SCIENCES INC. (US) 2023-11-21 US disclosed
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC. 2023-09-07 US disclosed
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC. 2017-05-25 US disclosed
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2016-10-06 US disclosed
US-20140024776-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS OLIGASIS (US) 2014-01-23 US disclosed
US-20130045522-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES OLIGASIS (US) 2013-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 PRKCA 2106/4885MAPT 2256/4885GRIN2D 2542/4885
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 PRKCA 2106/4885MAPT 2256/4885GRIN2D 2542/4885
US-20170143841-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG PRKCA 2137/4885MAPT 2483/4885GRIN2D 1756/4885
US-20140024776-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG PRKCA 2137/4885MAPT 2483/4885GRIN2D 1756/4885
US-11819531-B2 Multifunctional zwitterionic polymer conjugates PHOSPHO1, MSN, ZW10 PRKCA 2106/4885MAPT 2256/4885GRIN2D 2542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.