SCHEMBL14720593

SCHEMBL14720593

CC(C)(SCCC(=O)O)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.48
LMNA P02545 4/20 0.46
KMT2A Q03164 2/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
NAALAD2 Q9Y3Q0 1/20 0.38
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
CYP1A2 P05177 2/20 0.37
ALKBH5 Q6P6C2 1/20 0.36
SUCNR1 Q9BXA5 1/20 0.36
EGLN1 Q9GZT9 1/20 0.36
FFAR3 O14843 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
SLC15A2 Q16348 1/20 0.35
ALDH1A1 P00352 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21600666 0.80 TSHR (0.52) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL8608901 0.80 TSHR (0.52) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL30200266 0.78 TDP1 (0.37) TSHRHSD17B10TDP1CYP2D6CYP2C19
SCHEMBL21840789 0.76 KIF11 (0.39) TSHRCYP2D6CYP2C19HIF1AALDH1A1
SCHEMBL11496709 0.74 TSHR (0.46) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL10433867 0.73 HSD17B10 (0.45) TSHRKMT2AHSD17B10TDP1ALDH1A1
SCHEMBL17461346 0.71 CYP1A2 (0.47) TSHRLMNAKMT2AHSD17B10TDP1
SCHEMBL9106803 0.71 HSD17B10 (0.48) TSHRKMT2AHSD17B10TDP1ALDH1A1
SCHEMBL7756194 0.71 HSD17B10 (0.48) TSHRKMT2AHSD17B10TDP1ALDH1A1
SCHEMBL30171043 0.71 TSHR (0.42) TSHRLMNAKMT2AHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10745411-B2 Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2020-08-18 US disclosed
US-20200048278-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INT (DE) 2020-02-13 US disclosed
US-20180072754-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INT (DE) 2018-03-15 US disclosed
US-9802954-B2 Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-10-31 US disclosed
US-20170008903-A9 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-01-12 US disclosed
EP-2748156-B1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INT (DE) 2015-12-16 EP disclosed
US-9150586-B2 Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-10-06 US disclosed
US-20150148322-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-05-28 US disclosed
US-20150045376-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-02-12 US disclosed
WO-2014124860-A1 SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-08-21 WO disclosed
US-20140228286-A1 SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-08-14 US disclosed
EP-2748156-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA Boehringer Ingelheim International GmbH (DE) 2014-07-02 EP disclosed
US-8609670-B2 Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-12-17 US disclosed
US-20130079359-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-03-28 US disclosed
US-20130059866-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-03-07 US disclosed
WO-2013026797-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200048278-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, CYSLTR1, DHPS TSHR 2262/4885LMNA 4861/4885KMT2A 4102/4885
US-20180072754-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, CYSLTR1, DHPS TSHR 2262/4885LMNA 4861/4885KMT2A 4102/4885
US-10745411-B2 Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma CBS, DHPS, TPMT TSHR 2044/4885LMNA 4829/4885KMT2A 3799/4885
US-20130079359-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, SQOR, TST TSHR 2237/4885LMNA 4854/4885KMT2A 3735/4885
US-20140228286-A1 SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS PDE4B, PDE3B, PDE4A TSHR 1817/4885LMNA 3583/4885KMT2A 2236/4885
US-20130059866-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, SQOR, TST TSHR 2237/4885LMNA 4854/4885KMT2A 3735/4885
US-20170008903-A9 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, CYSLTR1, DHPS TSHR 2262/4885LMNA 4861/4885KMT2A 4102/4885
US-20150148322-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, SQOR, TST TSHR 2237/4885LMNA 4854/4885KMT2A 3735/4885
US-20150045376-A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA CBS, CYSLTR1, DHPS TSHR 2262/4885LMNA 4861/4885KMT2A 4102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.