Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | HTR3A | P46098 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | HRH2 | P25021 | 2/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338359 | 1.00 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| SCHEMBL29773377 | 1.00 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| Hydrochloric Acid SCHEMBL30695614 | 0.98 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| Hydrochloric Acid SCHEMBL16151212 | 0.98 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| SCHEMBL13057071 | 0.84 | HTR1A (0.57) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| SCHEMBL17777985 | 0.82 | TDP1 (0.49) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| SCHEMBL3859717 | 0.82 | CYP3A4 (0.52) | SLC6A4SLC6A3SLC6A2TDP1HTR1A | |
| SCHEMBL76793 | 0.82 | HAO1 (0.55) | SLC6A4TDP1HTR1AHTR3ACYP1A2 | |
| SCHEMBL29475022 | 0.82 | HAO1 (0.55) | SLC6A4TDP1HTR1AHTR3ACYP1A2 | |
| SCHEMBL18600516 | 0.81 | NPC1 (0.42) | SLC6A4SLC6A3SLC6A2TDP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101524-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L FINE CHEM PRIVATE LIMITED (IN) | 2024-03-28 | — | — | US | claimed |
| EP-4247802-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L Fine Chem Private Limited (IN) | 2023-09-27 | — | — | EP | claimed |
| WO-2022254248-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L FINE CHEM PRIVATE LIMITED (IN) | 2022-12-08 | — | — | WO | claimed |
| US-20180237386-A1 | Process For Preparation Of Vortioxetine Hydrobromide | AMNEAL PHARMACEUTICALS COMPANY GMBH (CH) | 2018-08-23 | — | — | US | claimed |
| EP-3337789-A1 | PROCESS FOR PREPARATION OF VORTIOXETINE HYDROBROMIDE | Amneal Pharmaceuticals Company GmbH (CH) | 2018-06-27 | — | — | EP | claimed |
| US-9920021-B2 | Method of preparing vortioxetine | ZENTIVA K.S. (CZ) | 2018-03-20 | — | — | US | claimed |
| US-20170204074-A1 | METHOD OF PREPARING VORTIOXETINE | ZENTIVA K.S. (CZ) | 2017-07-20 | — | — | US | claimed |
| CN-104829557-B | A kind of noval chemical compound 1 [2（2,4 3,5-dimethylphenyl sulfenyls）Phenyl] 2 oxygen piperazines and preparation method thereof and the application in Vortioxetine synthesis | 山东百诺医药股份有限公司 | 2017-06-27 | — | — | CN | claimed |
| EP-3166926-A1 | METHOD OF PREPARING VORTIOXETINE | Zentiva K.S. (CZ) | 2017-05-17 | — | — | EP | claimed |
| WO-2017029377-A1 | PROCESS FOR PREPARATION OF VORTIOXETINE HYDROBROMIDE | AMNEAL PHARMACEUTICALS COMPANY GMBH (CH) | 2017-02-23 | — | — | WO | claimed |
| WO-2016079751-A2 | A PROCESS FOR PREPARATION OF VORTIOXETINE AND POLYMORPHS THEREOF | MEGAFINE PHARMA (P) LTD. (IN) | 2016-05-26 | — | — | WO | claimed |
| WO-2016004908-A1 | METHOD OF PREPARING VORTIOXETINE | ZENTIVA, K.S. (CZ) | 2016-01-14 | — | — | WO | claimed |
| US-20240101524-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L FINE CHEM PRIVATE LIMITED (IN) | 2024-03-28 | — | — | US | disclosed |
| EP-3810582-B1 | A ONE-POT ORGANO-PSEUDOCATALYTIC C-H ACTIVATION APPROACH FOR THE PREPARATION OF VORTIOXETINE AND VORTIOXETINE INTERMEDIATE | VIO AG PHARMACEUTICALS S A (GR) | 2024-01-03 | — | — | EP | disclosed |
| EP-4247802-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L Fine Chem Private Limited (IN) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022254248-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | R L FINE CHEM PRIVATE LIMITED (IN) | 2022-12-08 | — | — | WO | disclosed |
| WO-2015114395-A1 | PROCESS FOR THE PREPARATION OF VORTIOXETINE SALTS | EGIS GYÓGYSZERGYÁR ZRT. (HU) | 2015-08-06 | — | — | WO | disclosed |
| WO-2014161976-A1 | NEW PROCESS FOR THE SYNTHESIS OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL)PIPERAZINE | LEK PHARMACEUTICALS D.D. (SI) | 2014-10-09 | — | — | WO | disclosed |
| WO-2013026455-A1 | PERMANENTLY POSITIVELY CHARGED ANTIDEPRESSANTS | AARHUS UNIVERSITET (DK) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013026455-A1 | PERMANENTLY POSITIVELY CHARGED ANTIDEPRESSANTS | AARHUS UNIVERSITET (DK) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180237386-A1 | Process For Preparation Of Vortioxetine Hydrobromide | SLC6A4, SLC6A3, SLC6A2 | SLC6A4 1/4885SLC6A3 2/4885SLC6A2 3/4885 |
| US-20240101524-A1 | A METHOD FOR PREPARATION OF 1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL) PIPERAZINE AND ITS SALTS | TPMT, HTR2A, HTR2C | SLC6A4 356/4885SLC6A3 629/4885SLC6A2 328/4885 |
| US-20170204074-A1 | METHOD OF PREPARING VORTIOXETINE | HTR5A, HTR1A, TPH1 | SLC6A4 40/4885SLC6A3 75/4885SLC6A2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.