Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14728249 | 0.87 | CCR2 (0.32) | PIK3CDPIK3CB | |
| SCHEMBL14728428 | 0.83 | ROCK2 (0.30) | — | |
| SCHEMBL14728235 | 0.81 | ADCY10 (0.31) | ALDH1A1 | |
| SCHEMBL14728328 | 0.77 | PIK3CB (0.55) | PIK3CDPIK3CB | |
| SCHEMBL14728405 | 0.77 | PIK3CD (0.35) | PIK3CDPIK3CB | |
| SCHEMBL14728443 | 0.77 | USP2 (0.30) | USP2 | |
| SCHEMBL14728548 | 0.77 | PIK3CB (0.32) | PIK3CDPIK3CB | |
| SCHEMBL14720445 | 0.72 | KDM4E (0.42) | USP2PIK3CDPIK3CBTSHRHSD17B10 | |
| SCHEMBL14728354 | 0.70 | PIK3CB (0.45) | PIK3CDPIK3CB | |
| Acetic Acid SCHEMBL14720357 | 0.68 | KDM4E (0.43) | USP2PIK3CDPIK3CBTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |