Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721568 | 0.72 | PIK3CB (0.42) | PIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL14728249 | 0.72 | CCR2 (0.32) | PIK3CBPIK3CDPIK3CG | |
| SCHEMBL14728443 | 0.67 | USP2 (0.30) | — | |
| SCHEMBL14728601 | 0.66 | PIK3CB (0.34) | PIK3CBPIK3CDPIK3CG | |
| SCHEMBL14728428 | 0.65 | ROCK2 (0.30) | — | |
| SCHEMBL14728544 | 0.64 | PIK3CB (0.56) | PIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL10263400 | 0.59 | CYP2A6 (0.42) | — | |
| SCHEMBL15762046 | 0.58 | MAOA (0.37) | — | |
| SCHEMBL3306785 | 0.58 | ESR1 (0.47) | — | |
| SCHEMBL16994800 | 0.56 | PARP1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028263-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |